Synthesis Of 1,2,5,6-tetrahydropyridine And 1,4-Dihydropyridine Derivatives Catalyzed By NO -PcFe (â…¢) @C

Phthalocyanine and its derivatives are wildly used in many areas, for example: dye enriched, sterilization, bleaching fabrics, photodynamic therap, biomimetic catalysis, biosensors and so on. Metal phthalocyanines are usually used as catalysts in redox, rearrangement, D-A and other reactions. Metal phthalocyanines possess some advantages such as high catalytic activity, environment-friendly, and easily separated from the reaction system when they are used as catalysts.With the good biological activity in the field of medicine synthetic drugs for treating cardiovascular and cerebrovascular diseases,1,2,5,6-tetrahydropyridine and 1,4-dihydropyridine are very important drug intermediates. Series of multi-substituted 1,2,5,6-tetrahydropyridine and 1,4-dihydropyridine derivatives are successfully synthesized through the method of "one pot synthesis" and NO2-PcFe(â…¢)@C as catalyst from the perspective of green synthesis. This method have the advantages of simple operation, no pollution, high yield, easy purification.This paper is divided into three parts:the first part is introduced the synthesis and applications of phthalocyanine,1,2,5,6-tetrahydropyridine and 1,4-dihydropyridine derivatives briefly; the second part, with aromatic aldehydes, aromatic amines, ethyl acetoacetate as raw materials, NO2-PcFe(â…¢)@C as catalyst, a series of multi-substituted 1,2,5,6-tetrahydropyridine derivatives were achieved; the third part, using NO2-PcFe(â…¢)@C as catalyst, a series of multi-substituted 1,4-dihydropyridine derivatives were synthesized in a high yield from the raw materials aromatic aldehydes, double ketone, ethyl acetoacetate, ammonium acetate.