| PartⅠ: The review summarizes the development of diazo chemistry and focuses on the progress that has been made very recently, particularly in the field of catalytic metal carbine derived from α-diazo carbonyl compounds transformations. The recent progress of them as precursors of metal carbenes in organic synthetic reactions, such as the cyclopropanation reaction, ylide reaction, X-H bood insertion reaction, 1,2-migration reaction of diazo carbine, was summaried in details. According to the research results we designed transition metal-catalyzed reaction of α-diazo carbonyl compounds participate in amides derivatives synthsis. Amides derivatives is a kind of very important nitrogen compounds, has the vital significance in the field of organic chemistry. It not only can be used as a basic raw materials or intermediates in organic synthesis and also widely exists in pesticide, medicine, dyestuff, natural products, polymer materials and fine chemical products. Studies on the synthesis of highly substituted amides with α-diazo carbonyl compounds by transition-metal catalyzed. Furthermore, the reaction conditions and a possible mechanism is proposed. All of the new compounds were characterized by not only NMR, but also the single-crystal X-ray analysis in the case of the product C.PartⅡ: we designed and synthesized a N, N- bidentate ferrocenyl derivative, and then focus on the study of metal ions recognition properties of the compound. Specific work is as follows: To a well-stirred solution of 1,1’-Ferrocene dicarboxaldehyde(1mmol) in 5ml DMSO was added 2-aminothiophnol(2mmol) at 65℃ for 6h. We synthesized by 1, 1’- bis(benzothiazol-2-yl) ferrocene s. It were characterized by1HNMR、13CNMR. And the structure of s was further determined by X-ray diffraction. And then focus on the study of ions recognition properties of s. The result showed s is a new class of Pb2+ chemosensor that displays not only the capability for fluorescent detection, but also the facile “naked-eye” detection of Pb2+. |
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