Preparation And Release Behavior Of Spi-based Polymer Hydrogel

Soy protein isolate whose surface contains many lively group, is a natural biopolymer material. Natural polymers as drug delivery systems have some advantages, such as biodegradability, biocompatibility, plentiful supply and low cost.Based on the above advantages, this paper mainly uses Soy protein isolate(SPI) as a raw material, while NIPAM, AA and NVP as a comonomer, to prepare the environmental sensitivity intelligent hydrogels. The structure, thermal stability and hydrogel surface morphology of copolymers has been characterized by using flourier-infrared spectrometry(FT-IR), thermogravimetric analysis(TG) and scanning electron microscope(SEM), respectively.Firstly, SPI is a kind of natural polymer materials. This paper introduces the SPI structure, composition and properties. Potential applications of SPI Include use in food, biomedicine, fibre,adhesives. SPI as drug carrier can maintain the activity of the drug molecules, controlled release of drug molecules have very good performance, as a drug delivery system has good prospects for development.Secondly, a novel drug carrier with graft polymerization hydrogels SPI/P(NIPAM-co-AA) based on Soy protein isolate(SPI), N-isopropyl acrylamide(NIPAM) and Acrylic acid, is reported. SEM pictures show tha t the SPI/P(NIPAM-co-AA) have an perfect pore structure which can also be used as a drug carrier. TG results indicate that the thermal stability of SPI/P(NIPAM-co-AA) has been significantly improved. The hydrogel swelling properties in different media. The results showed that the hydrogels significantly pH, temperature and salt sensitivity. Besides, the vitro drug release behavior of SPI/P(NIPAM-co-AA) is investigated under different environments by using model drugs such as Doxorubicin hydrochloride(Dox·HCl), Bovine Serum Albumin(BSA) and Rhodamine B(RB). The results suggest that SPI/P(NIPAM-co-AA) can be exploited as a carrier candidate for drug delivery.Thirdly, in order to expand the application of Soy protein isolate, a Multisensitive SPI/PDMAEMA hydrogel has been prepared, in which Soy protein isolate is a starting material while N,N-dimethylaminoethyl methacrylate(DMAEMA) is modifying monomers. By using FT-IR, TG and SEM respectively, the structure, thermal stability and hydrogel surface morphology of hydrogel SPI/PDMAEMA are characterized. The results show that SPI/PDMAEMA has an excellent pH, temperature and salt sensitivity stimuli-responsive. What’s more, the vitro drug release behavior of SPI/PDMAEMA is investigated under different environments by using model drugs such as Doxorubicin hydrochloride(Dox·HCl), Bovine Serum Albumin(BSA) and Rhodamine B(RB). The results also suggest that SPI/PDMAEMA can be exploited as carrier candidate for drug delivery.Finally, Soy protein isolate(SPI) for the raw material, the polyvinyl pyrrolidone(PVP) is introduced as a monomer to prepare Soy protein isolate-based hydrogel SPI/PVP. By respectively using FT-IR, TG and SEM, the structure, thermal stability and hydrogel surface morphology of copolymers are characterized. The results show that SPI/PVP has a complex porous structure which can also be used as a drug carrier. TG results indicate that the thermal stability of SPI/PVP has been significantly improved. Next, The hydrogel swelling properties in different media. At last, the vitro drug release behavior of SPI/PVP are investigated under different environments by using model drugs such as Doxorubicin hydrochloride(Dox·HCl), Bovine Serum Albumin(BSA) and Rhodamine B(RB). The results suggest that SPI/PVP can be exploited as a carrier candidate for drug delivery.To be concluded, the paper prepares a Multisensitive hydrogel, showing a good release property in vitro. This research broadens the study range of natural polymer protein-based drug carrier. There is no doubt that it will have a bright application prospect in biomedical field.