Fabrication Of Silica Hollow Micropheres And The Appication In Controlled Release

In the past few years, the materials science developed along the direction of the intercross of the many scientific fields. The research was not restricted within the traditional compound, but turning to the hybrid of the organic, inorganic, macromolecule and the biomaterials. In the most hybrid materials, core/shell materials have been one of the focuses of many scientists due to their features in structure, size and composition, core/shell materials have unusual properties in optics, electronics and chemistry. The preparation of the core/shell materials is various; materials with the same structure and composing can be prepared with many methods. According the state of the system, the preparation methods composed homogeneous and the inhomogeneous methods. There are many merits such as simplicity, high repeating ration and being foreseeable for the hard template method; such a method is usually used in the preparation of core/shell materials. Nowadays, the preparation of the core/shell materials includes soft-template, hard-template, the combine of the soft-template and hard-template and the hydrothermal methods, etc.The standard of living is improved enormously, because of this, it is necessary to develop a new kind of drug delivery system, which can decrease the side-effect, improve the drug efficiency, prevent doing harm to human’s body. In this paper, we do some research on the mesoporous in controlled release.In this article, monodisperse polystyrene (PS) microspheres templates were produced by dispersion polymerization,adjust the amount of monomer, emulsifier and initiator, to adjust the microspheres particle size, and then we improved the surface character of the template by the simple sulfonation with concentrated sulfuric acid. Compared the microspheres, prepared by acid is better than the base method. Transmission scanning electron microscope (SEM), infrared spectra (IR), XRD and the fluorescence spectra were used to character the resulting products.Moreover, using PS as the template and the TEOS as silicon source, hollow SiO2 microspheres were prepared. The morphology and structure were characterized carefully.Finally, using aspirin as experimental drug, do some research of PS SPS and pH-sensitive hollow silica microspheres as drug carrier and drug release behavior.In this thesis, we focused on the synthesis of multifunctional nanocomposites based on highly ordered mesoporous silica and their applications in controlled drug delivery which have great theoretical and practical significations. The research relates to several hotfields. including life science, nano-science and technology and mesoporous materials science.