Synthesis And Structure Research Of Aminobenzoic Acid Chiral Derivatives And Their Coordination Complexes

Chirality plays a key role in nature, but it is also important in the development of life science, pharmaceutical engineering and materials science. Chiral metal complexes have attracted a lot of attention, due to their fantastic structures, topologies, applications of chiral separation and asymmetric catalysis. In recent years, the syntheses and applications of chiral metal complexes have been achieved successfully. However, it is still a challenge to improve the performance of materials in chiral separation and enantioselective catalysis.Natural chiral carboxylic acid compounds as one of an easy available and generally cheap starting materials are widely used in the field of constructing chiral metal complexes; due to ready, derivatives, and rich binding recognition sites. This dissertation describes our investigation of syntheses of chiral functional 5-aminoisophthalic acid derivatives and coordination-drived assemblies of their metal complexes. (1s)-(-)-camphanic acid and BOC-L-proline are introduced separately to 5-aminoisophthalic acid dimethyl ester under different condensation reactions. The solvent thermal method was employed to synthesis of copper(II) complexes with corresponding carboxylic acid ligands from intermediates hydrolysis reaction, and the copper(II) salt. As a result, by optimizing conditions,such as the different solvent, pH, temperature, four crystalline intermediates and two new types of copper chiral complexes are achieved. The structure of the compounds are determined with MS, HNMR, EA, IR, PXRD and gas selectivity adsorption properties and chiral separation experiments.Additional, two series of chiral acid ligand from BOC-L-proline modified ethylp-aminobenzoate and L-(+)-tartaric acid modified ethyl amino acid were synthesized.