Synthesis And Property Investigation Of Bone Glue Based On Al(â…¢), Sn(â…£) And Cu(â…¡) Modification

Bone glue, a kind of green-natural polymer adhesive, has a long history of usage. There were many problems, such as a high freezing point, poor water resistance and viscosity instability, in the use of it which restrict its development and application. In this study, two methods were taken to solve these problems to prepare a type of environmentally friendly of bone glue which has low freezing point, excellent viscosity, outstanding water resistance, firstly the alkali hydrolysis and metal ions coordination of bone glue, secondly the alkali hydrolysis, dispersed and metal ions coordination of bone glue.Caustic soda has been taken to alkali hydrolysis then aluminium sulfate was introduced to the bone glue.The effects of the alkali hydrolysis time, the alkali quantity, pH, aluminium sulfate on the viscosity and freezing point of modified bone glue have been investigated, and the optimal conditions of preparation modified bone glue were obtained by the single factor experiment method. The optimal conditions were:the dry bone glue was 25 g, the distilled water was 30 mL, the alkaline hydrolysis time was 100 min, the alkali content was 1.0 g, pH was 5 and the aluminium sulfate was 0.8 g. The modified bone glue had the outstanding water resistance, freezing point at -2℃, viscosity at 0.6 Pa·s, shear strength was 5.88 MPa, and contact angle increased from 41.28° to 80.57°. There were still many problems, such as low viscosity and insufficient initial adhesion.A method was been taken to solve the low viscosity problem which were mentioned above, the alkali hydrolysis, dispersed and metal ions (Al3+/Sn4+/Cu2+) coordination of bone glue. The single factor experiment and response surface method were used for exploring the optimal conditions of preparing modified bone glue. The optimal conditions of Al3+ modified bone glue were:the dry bone glue was 25 g, the distilled water was 30 mL, the carbamide was 0.78 g, the lauryl sodium sulfate was 0.5 g, the aluminium sulfate was 0.8 g, and the coordination reaction temperature was 60.56℃. The Al3+ modified bone glue appeared many eminent performances, such as freezing point at 4.2℃, viscosity at 4.575 Pa·s, and contact angle at 91.87°. The optimal conditions of Sn4+ modified bone glue were:the dry bone glue was 25 g, the distilled water was 30 mL, the carbamide was 0.79 g, the lauryl sodium sulfate was 0.44 g, and the stannic chloride was 1.27 g. The Sn4+ modified bone glue had some good performances, such as freezing point at 4.4℃, viscosity at 1.902 Pa·s, and contact angle at 92.97°. The optimal conditions of Cu2+ modified bone glue were: the dry bone glue was 25 g, the distilled water was 30 mL, and the cupric sulfate was 1.0 g. The Cu2+ modified bone glue appeared many good performances, such as freezing point at 5℃, viscosity at 1.6 Pa·s, and contact angle at 92.57°. Compared with bone glue, most properties of the modified bone glue mentioned above had a big great improvements, such as freezing point, viscosity, contact angle and water resistance.After two aspects of work mentioned above, not only some problems were been resolved, but also optimized the preparation conditions of modified bone glue, and provided new methods for bone glue modification.