Study On The Synthesis Of New Quinazolines α1 Receptorblocker

In recent years, the medicine research on the treatment of prostate hyperplasia and high blood pressure turns to be a hotspot. In these kinds of medicines, the widest applied medicine at most of them is the quinazoline. Especially, in the treatment of high blood pressure, the quinazoline medicine have good effect and can be lower than an afferent resistance. So this kind of medicine has good market foreground. This kind of medicines all contain a major structure of 4-amino-6,7-dimetoxyquinazoline. And in recent years, there are a lot of reports of the synthesization of new compounds. Phenylpiperazine or aroxyalylamines integrating with quinazoline succeed in getting the end compound, which have tiny side-effect and high curative effect.We designed and optimized the synthetic route of new quinazoline compounds. In this paper, we used diethylamine as initial material, using halogenation to obtain bis (2-halogen) amine hydrohalogen, by the cyclizative condensation with substituted anilines to obtain phenylpiperazine with proton neutralization dose-sodium carbonate anhydrous and reaction solvent-ethanol. Then the product reacted with 2-chloro-4-amino-6,7-dimetoxyquinazoline to obtain the target compound. Besides we synthesized 5 new compounds, they were characterized by IR and 1HNMR.The study was also undertaken for a research on the enlargement of the experimental technology to look forward to a better application future.