The Effect Of Sulfuretted Hydrogen On Burned Rats’ Wound Healing

Objective To study the function and the significance of sulfuretted hydrogenin the process of healing of burn wound. Methods108healthy and eight weeks of rats(female and male were half-and-half) which were made a burn model in the back,wererandomly divided into3groups:control group,sodium hydrosulfide group(NaHS) andLD-propargylglycine group(PPG). The control group were injected0.9%sodiumchloride1ml once a day.NaHS group were injected NaHS56μmol·kg-1·d-1and the PPG groupwere inject-ed PPG45mg·kg-1·d-1.Eschar dissolution ratio，wound healing rate andhistopathological score would be recorded after1d,7d,14d,21d and28d fromburn.Results (1)NaHS group’s eschardi-ssolution ratio were lower than control groupand PPG group on the7th and14thd-ay after the rats were burned. The difference resultof other time phase was not statistically significant.(2)NaHS group’s wound healingrate was higher than con-trol group’s and PPG group’s,while PPG group’s wound healingrate was lower than NaHS group’s and control group’s.The difference result of othertime phase was n-ot statistically significant.(3)NaHS group’shistopathological scoreis higher th-an control group’s on the14th and21th days after that the rats wereburned. It’also higher than PPG group’s on the7th、14th and21th days.PPG group’shistopa-thological score is lower than control group’s on the14th and21th days aftert-he rats were burned.Conclusion The H2S/CSE system has participated in the healingprocess of deep partial thickness burn wound in rats. Extrinsic H2S can shorten thewound healing time and delay eschar dissolution time.It’s showed that raising thesulfuretted hydrogen can promote burn wound healing under the eschar.