| Objective：Part of Clinical Epidemiological Investigation：To provide materials forclinical practice of treatment and prognosis by clinical epidemiology of urolithiasis inJiangxi Province which provide patients with urinary calculi of characteristics,distribution features, stones composition and the present status based on urolithiasisin the existed hospital clinical records.Part of Gene Polymorphism：To explore the association of MTNR1A genepolymorphisms with susceptibility of idiopathic calcium oxalate urolithiasis of Hanpopulation in Jiangxi Province.Methods：Part of Clinical Epidemiological Investigation：From various cities in Jiangxiprovince of administrative distribution, we have randomly chosen one or two level3first-class hospital and the First Affiliated Hospital of Nanchang University, in whichextracting all the cases of2012and first half year of2013, with medical recordinformation about patients with urinary calculi for retrospective investigation.Part of Gene Polymorphism：In this study,115people who had idiopathiccalcium oxalate stones and145healthy people were enrolled as control group.MTNR1A rs13140012site A/T polymorphism was determined by real-timepolymerase chain reaction.Result：Part of Clinical Epidemiological Investigation：（1）The patients with urinarystone in2012in Jiangxi province accounted for37.10%of hospitalized patients inurology department with the same period. There were7497patients, The ratiobetween male and female urolithiasis patients is1.48:1. The summit clinical age isfrom41to60years old，which amounts to52.04％，about the half of the total. Theconstituent ratio of different kinds of urolithiasis is not the same．Kidney stones and ureteral calculi accounted for64.52%and58.50%respectively, bladder calculi was8.54%, and urethral calculi formation is the lowest of1.20%; The ratio between upperand lower urinary stones is9.54:1.The sex ratio in lower urinary calculi cases is15.84:1, the difference had obvious statistical significance.The sex ratio in upperurinary calculi cases is1.27:1,which is no significant statistical difference.(2) It isfound that farmers，of all cholelithiasis patients，which totally account for51.31%andis in slightly higher amount．And the education of patient is given priority to withjunior school and elementary high school (67.39%). We have got5323records ofurolithiasis’ body mass index (BMI) from medical records, the average body massindex was22.35+/-3.26, the overweight patients accounted for22.96%, obese patientsaccounted for5.82%and underweight patients is11.59%.(3) Back pain for the vastmajority of the main symptoms of urinary stone disease which accounted for67.85%;the urolithiasis patients who have no symptoms and were diagnosed in healthmaintainance screening accounted for9.95%. There are about25.38%of theurolithiasis patients who had a clear history of urinary calculi tract.(4) In5876cases,which blood type is known, the type O blood is most (40.97%), and type ABblood at least (6.83%). According to calculus components,567urinary calculipatients divided into the following2groups.The first group is mixed componentcalculus group the total cases of which is219, accounted for38.62; the second groupis single component calculus group the total cases of which is220,accounted for38.80%. Mixed stone are mainly composed of calcium oxalate mixed carbonateapatite, a total of219cases (38.62%), the main components of calcium oxalate stonefor stone accounted for90.84%of all proportion calculi specimens.Part of Gene Polymorphism：Differences of age, gender and body massindex(BMI) between the two groups were not statistically significant. T allelefrequency in ICOS group was obviously higher than that of healthy control group,with significant difference (p <0.001).Conclusions：1. The patients with urinary stone in2012in Jiangxi province，where is prone tocalculi，accounted for37.10%of the urology hospitalized patients with the same period. The ratio between male and female urolithiasis patients is1.48:1and high-riskage is41~60years old. Urinary stone disease outbreak in our province is highestform May to August.2. Farmers served as the main component of professional composition, andeducation background is given priority to with junio school and elementary highschool.3. Lower urinary stones affected more men than women.4. Urolithiasis patients have a high rate of recurrence.5. The most single component calculus group is calcium oxalate calculus. Mixedstone are mainly composed of calcium oxalate mixed carbonate apatite.6. There is significant association between MNTR1A polymorphism withidiopathic calcium oxalate urolithiasis.7. Allele T is an good genetic marker for idiopathic calcium oxalatenephrolithiasis. |
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