The Technical Parameters Study On The Synthesis Of Neohesperidin Dihydrochalcone

Neohesperidin dihydrochalcone(NHDC) is obtained by the hydrogenation ofNeohesperidin, as representative dihydrochalcone of Flavonoids. NHDC is afunctional sweetener which can suppress bitterness and improve flavor, and has highsweetness, low calorie, lasting sweet, stable, non-toxic, so that it is widely used infood, pharmaceuticals and feed industry.The main contents of this paper are divided into three parts:First, The clinical application、 research status and development trends ofFlavonoids are reviewed. Moreover, the characteristics of NHDC are summarized.Both domestic and foreign literature of synthesis routes are reviewed in order toscreen out a industrial production of synthetic route.Second, with Naringin as the raw materials, Neohesperidin dihydrochalcone, thefinal product, has been synthesized by Hydrolysis, Condensation, Hydrogenation.HPLC analysis conditions are determined for every step to detect the end of thereaction and assess the qualitative and quantitative of the final product, what，s more,the1HNMR and MS is used to conform the structures of intermediates and targetproduct, in order to get the best process parameters, conditions of all the reactions areoptimized, Industrial production is possible with an overall yield of57.6%by theoptimal conditions which have been shown to have high reliability by theamplification experiments.Third, a synthetic route, which has features easy access to raw material, mildreaction conditions and high yield, is obtained by optimizing all of the reactionconditions. Meanwhile, the solutions of some problems are proposed and the furtherresearch about the synthesis of NHDC is still needed in the future.