A Meta-analysis Association Between Cytotoxic T Lymphocyte Antigen-4Polymorphisms And Gastric Cancer Risk

【AIM】We want to investigate people that correlation between cytotoxic Tlymphocyte-associated antigen4gene (CTLA-4) and gastric cancer risk.【METHODS】Two reviewers independently searched PubMed, FMRS, CNKI,VIP and WanFang Data from January1st1990to may1st2014for case-control studies on thecorrelation between CTLA-4and gastric cancer risk. According to inclusion andexclusion criteria, two reviewers independently screen literature, extracted the data,and assessed the methodological quality. Then meta-analysis was performed usingRevMan5.2software.【RESULTS】A total of10articles comprising case-control study concerning the CTLA-4+49A/G， CTLA-4-1661A/G, CTLA-41722T/C and CTLA-4-318T/C polymorphismswere included in the meta-analysis. However, the CTLA-4+49alleles and CTLA-4-318alleles are not associated with genetic susceptibility to gastric cancer. The resultssuggested the CTLA-4-1661A/G polymorphism was significantly associated with anincreased gastric cancer risk (AG vs. AA: OR=2.04，95％CI=1.60-2.61P<0.00001;AG/GG vs. AA: OR=1.79，95％CI=1.43-2.25P<0.00001). For CTLA-4-1722T/Cpolymorphism, the results showed that the CTLA-4-1722T/C polymorphism wassignificantly associated with an increased gastric cancer risk (TT vs. CC, OR=1.66，95％CI=1.05-2.62，P=0.03； TC vs CC, OR=2.11，95％CI=1.05-4.24，P=0.04；TT/TC vs CC, OR=1.84，95％CI=1.20-2.82，P=0.04).【CONCLUSION】The CTLA-4+49alleles and CTLA-4-318alleles are not associated with geneticsusceptibility to gastric cancer. But the CTLA-4-1661A/G和-1772T/C haveessentially associated with an increased risk of gastric cancer. CTLA-4-1661AG andGG allele carrying individuals may increase the incidence of gastric cancer. CTLA-4-1772allele carrying TT and TC may increase the incidence of gastric cancerin the individual.