Relationship Between Serum Gamma-glutamyltransferase And The Risk Factors Of Chronic Kidney Disease In Fuzhou Adult Population

Background and aims: Serum gamma-glutamyltransferase (GGT) has beentraditionally used as a marker of excessive alcohol intake and as a screening tool forhepatobiliary disease, despite its wide presence throughout the body.However, epidemiological studies suggest that elevated levels of GGTis a predictor of chronic kidney disease in nonhypertensive and nondiabetic.Currently,the association of serum GGT concentrations with chronic kidney disease has seldombeen established in the southeast coastal area population in China.Objects and Methods: We performed a cross-sectional analysis of data from PhysicalExamination Center of Fujian Provincial Hospital. We examined the associationbetween serum GGT concentrations and the risk factors of chronic kidney disease inrepresentative samples of354adults aged18years or older.Results：1.After adjustment for sex and age, the serum GGT is positively correlatedwith serum lipid, fasting blood-glucose, serum uric acid and blood pressure(male/female：TG0.431/0.406、TC0.253/0.249、LDL0.262/0.296、UA0.287/0.370、SBP0.12/0.322、DBP0.283/0.205, P<0.05）.2.According to the quartiles, we divided serum GGT into4subgroups. Therewere significant differences in these subgroups. The serum lipid, fastingblood-glucose, serum uric acid and blood pressure was elevated with the upgrade ofserum GGT concentrations among the subgroups. The differences was statisticalsignificance (P<0.05).3.Modeling by multiple linear regression analysis, we found linear relationshipbetween serum GGT concentrations and independent variables including serumtriglycerides, serum uric acid and fasting blood-glucose(β=0.375、0.243、0.194，P<0.05）.4.Multiple logistic regression analysis showed that each odds ratio (95%confidence interval) of the risk factors of CKD associated with subgroup4wasapparently ascendant comparing to subgroup1of GGT. The differences was statisticalsignificance (P<0.05).Conclusions: These results show an independent relationship between increasedserum GGT concentrations with hyperlipidemia, hyperuricemia, hyperglycemia andhypertension, which are known as the risk factors of chronic kidney disease in Fuzhouadult population.