Study On The Preparation And Quality Standard And Pharmacokinetics Of Disperible Tablets Of Radix Puerariae Flavones

Objective: To examine a suitable prescription for the disperible tablets of PuerariaLobata flavone and study the preparation process. Study and comparison the serumconcentration and pharmacokinetics in rats of disperible tablets of Pueraria Lobata Flavoneand Yufeng Ningxin Tablet.Method: The preparative process was scanned out by singlefactor test and orthogonal design. Feed mice of disperible tablets of Pueraria LobataFlavone and Yufeng Ningxin Tablet，used the way of HPLC test the serum concentration ofdifferent times and design conditions of Pharmacokinetics by statistical software.Result: The optimized disperible tablets disintegrated in50seconds， and thedispersibLe uniform was excellent. The released rate parameters of dispersible tablets wereremarkably smaller than of the control group(P＜0.01). The Cmax of Disperible tablets ofPueraria Lobata Flavone and merchant tablet were (20.21士0.18)and(9.90士0.25)μg/mL.The dispersible tablet Tmax for (0.50±0.03)h，merchant tablet is (1.09±0.02)h.Conclusion: Disperible tablets of Pueraria Lobata flavone had the characteristic offast and homogeneously dispersing and quick releasing of active constituents. Disperibletablets of Pueraria Lobata Flavone has absorbs， the appearance quickly is rapaid and thePharmacokinetics was superior to the control group.