The Research Of Heroin Addicts’ Brain Function Changes Based On ALFF, And Resting State FMRI Of MMT Efficacy Evaluation

ObjectiveIt’s aimed to clear heroin addicts’ abnormalities of local neuronal activity, explore thedifferences of spontaneous activity of neurons in the brain between normal and heroinaddicts, further detect the effect of methadone maintenance treatment to intensity changeand brain function of heroin addicts spontaneous brain activity, and evaluate the therapy.MethodsExperiment1: using3.0T magnetic resonance scanner, we collected the resting statefMRI data of20male heroin addicts (heroin group) and15demographic matching healthyvolunteers (control group), and then find the differences between the two groups in lowfrequency amplitude. Experiment2: using3.0T magnetic resonance scanner, wecollected the resting state fMRI data of19methadone maintenance patients and13heroin addicts, and compared low frequency amplitude between them.ResultsExperiment1: Compared with the control, low amplitude activity in rostral cingulategyrus (bilateral anterior cingulate gyrus, medial prefrontal cortex) of heroin groupdecreased significantly, and no enhancement area. Experiment2: Compared with heroingroup, the low-frequency amplitude in left medial prefrontal cortex, inferior frontalgyrus, angular gyrus, precuneus and right lobulus parietalis inferior decreased in methadonemaintenance group, however, the activity of bilateral postcentral gyrus, right lenticularnucleus and precentral gyrus was increased.ConclusionThe abnormal resting state function fo rostral cingulate regions of heroinaddicts, may lead to cognitive impairment, and play an important role inrelapse. Long-term MMT could improve the body movement, sensation and otherfunction of heroin dependence, which could reduce the withdrawal symptoms and help theaddicts back to society. However, methadone likewise can reduce the working memory,increase the impulsion and negative emotion, which may be the neural basis ofhigh relapse rate in the process of MMT. Both negative and positive effect can MMT do,which may play the main effect will become further target of our research.