Study On Pharmacognosy And The Different Formulations Of Oral Ulcer Treatment On Berberis Amurensis Rupr

Berberis amurensis Rupr mainly distributed in Northeast of China, people always use its roots treatmentbacillary dysentery, enteritis and other diseases. Currently, Berberis amurensis Rupr in Northeast on chemicalcomposition of different parts and other aspects of demand is rarely reported,So this thesis emphasison thePharmacognosy of roots and fruits of Berberis produced in northeast of China, the alkaloids antibacterialactivity and the treatment of oral ulcers different formulations of Berberis amurensis Rupr.1.On pharmacognosy,Identification of Berberis amurensis Rupr root and fruit watermelon on basedsources，raits and microscopic aspects，Observed characteristics of big-leaf barberry root powder bymicroscopy,We found that it was a lot of cork cells, wood fiber, conduit, bast fibers and parenchyma cells，Stone cells were relatively few and scattered, mostly slender fibrous cells.Wood fiber wall was thin, bunchedexist，The Endocarp cells in fruit powder of large leaves of Berber were yellow, thin-walled, polygonal orrectangular and had a larger quantities；the Fruit cells showed red-brown, polygonal or rectangular;Endosperm cells showed a pale yellow, thin walls.2.On the antibacterial activity,in root alkaloids of big leaf barberry: Big leaf barberry root alkaloids with80%ethanol extract had optimal effect，attain23.5%。Alcohol group inhibitory effect on water extractiongroup. After two weeks of drug treatment, the three groups（alcohol extract drug group, water extraction druggroup, Dicetel drug group）loose stools level significantly lower (P <0.01),and the efficacy of alcohol extractdrug group was better than others groups.3.Different forms aspects：take the appearance，adhesion and dissolution time for testing，Screening Berberisamurensis Rupr alkaloids oral ulcer film forming material, By orthogonal design to look and release as anindicator，Preferably the best prescription of the preparation, Validation tests show that the prescriptionprocess convenient, reasonable, and easy.Explore the optimal of prescription spray, the mist particles of spraywere smaller，outside for oral, skinand other body parts. It was used oral, skin and the other body parts. Topically Apart from medical effects ofthe drug，in the surface layer of film of wound，it has a closed and protective effect. Drugs directly to the siteof action or absorption site, the role of rapid and less dosage, side effects. The effect is significant.ItwasFast-acting and less dosage,Through the clinical experiment on modified Berberis amurensis Rupr Three formulations treating oralulcer, we observed the clinical curative effect.pharmacological activity: In vitro antibacterial activity and vivo antibacterial activity in mice.2, The90cases of patients who all accord with the diagnostic criteria were randomly divided into the treatment group and control group. The treatment group has60cases, while the control group also has30cases. We Comparethe clinical symptoms before and after treated.Clinical Case Analysis: According to the clinical treatment of90cases have been reported in patientsrecovered75cases, accounting for83.3%.30patients with clinical symptoms of the implementation ofroutine treatment response rate63.3%, the implementation of conventional treatment increased leaf barberryalkaloids tablet therapy clinical remission of symptoms in30patients (83.3%), the implementation ofconventional treatment increased leaf Berberis alkaloids film formers clinical symptoms of patients treated30cases of remission rate was93.3%, dosage group and the conventional group therapy was statisticallysignificance (P <0.05)Through the clinical experiment on modified Berberis amurensis Rupr film formulations treating oralulcer, has a remarkable curative effect.