Comparative Study Of Arterial Spin Labeling And Dynamic Susceptibility Contrast-enhanced MRI In Cerebral Ischemia Penumbra

Objective：To compare the value of arterial spin labeling（ASL）and dynamic susceptibilitycontrast-enhanced（DSC）MRI in evaluation the ischemic penumbra of stroke.Materials and MethodsRoutine MRI scanning、DWI、ASL and DSC were performed on34patients withacute ischemic stroke within12hours of symptom onset. TI chooses1800ms onsingle-phase ASL，TI choose300ms、600ms、900ms、1200ms、1500ms、1800ms、2100ms、2400ms on multi-phase ASL. DSC using echo planar free attenuation (EPI-FID)sequence，collected40times，using the high pressure syringe rapid bolus injection ofGd-DTPA0.2mmol/kg，flow rate with5mL/s. Hypoperfusion，hyperfusion，normalperfusion and local high perfusion of2kinds of technology were observed。The statistic method is statistics package for social science（SPSS）17.0. Bothmethods，combined with DWI，were used to determine the ischemic penumbra, the resultswere qualitative analysis by Mann-Whitney. The maximum lesion DWI displayed as thestandard level，2kinds of technology of abnormal perfusion area were measured，theresults were quantitative analysis by a independent samples t test.ResultsQualitative analysis demonstrated agreement between the two techniques in32of34patients (hypoperfusion, n=30，of which with IP；n=17，without IP，n=13； hyperfusion，n=2).Quantitative analysis indicated that the ASL and DSC of the largest abnormalperfusion lesion，SDSC=27.17±14.07cm2，SASL=29.10±12.72cm2. Both qualitative andquantitive analysis revealed there were no significant difference between the twotechniques (P>0.05).In two studies，the two techniques disagreed when ASL demonstrated hyperfusion andDSC demonstrated normal perfusion.②ASL demonstated local high perfusion inhypoperfusion zone edge of six studies.ConclusionThe noninvasive ASL technology and DSC technology has good consistency inevaluation of stroke IP.ASL is more sensitive in hyperfusion and local high perfusion of hypoperfusionarea (indicated collateral circulation).