Comparative Efficacy Of3C Solutions At Different Duration Of Type2Diabetes In The Program And With The Double C

Objective: Glucose monitoring and insulin pump program that3C jointretrospective glucose monitoring program differences that combined real-time double-Cfor different duration of type2blood glucose levels, blood sugar fluctuations and lowincidence of hypoglycemia in patients with diabetes, insulin pump comparison.Methods：Choose from December2012to January2014at the First AffiliatedHospital of Dalian Medical University, Department of Endocrinology, three63hospitalized patients with type2diabetes, the average duration of5.2years, glycatedhemoglobin (glycosylated hemoglobin, HbA1c)≥9%, were randomly divided for thegroup and the double C group3C,3C group using real-time dynamic insulin pump,double C group with continuous subcutaneous insulin infusion (continuoussubcutaneous insulin infusion, CSII) joint retrospective sustained glucose monitoringsystem (Continuous Glucose Monitoring System, CGMS),3C group divided by theduration of A1(duration≤1years), A2(duration>1year,≤5years), A3group(duration>5years). When fasting until bedtime fingertip fingertip blood sugar orglucose≤7.0mmol/L and the area under the curve of hyperglycemia≤2.2mmol/L,considered blood glucose. Comparison of the two groups before the day of treatmentand compliance mean blood glucose standard deviation difference hyperglycemia areaunder the curve, and the differences between different groups within the3C course theseindicators and analysis of relevant factors affecting the compliance time and total compliance rate of insulin.Results:1.3C treatment groups A1, A2, A3group weight, waist circumference,BMI, SBP, DBP, FPG, ALT, AST, BUN, Cre, Ccr, TC, HDL-C, LDL-C, CRP, HOMA-β,HOMA there were no significant differences (P>0.05) between-IR group, the durationbetween HbA1c, TG group, the difference was statistically significant (P <0.05),3Cgroup and double-C above baseline treatment groups were not significantly different(P>0.05).2.3C treatment groups A1, A2, A3between groups were no differences in the rateof blood glucose (P>0.05) were significant,3C group and double-C group, thedifference was not statistically significant (P>0.05).3C treatment groups A1, A2, A3group of blood glucose among an array of day was no significant difference (P>0.05),3C group and double-C group, the difference was not statistically significant (P>0.05).3.3C treatment groups A1, A2, A3mean blood group and two C treatment groupafter treatment, blood glucose standard deviation, high blood sugar before the areaunder the curve decreased significantly compared with treatment (P <0.05),pre-treatment and post-treatment mean blood glucose, standard deviation of bloodglucose, high blood glucose area under the curve between-group difference was notstatistically significant (P>0.05).4.3C treatment groups A1, A2, A3group of blood glucose over time among thetotal insulin was no significant difference (P>0.05).5.Views3C hypoglycemia treatment group was significantly less than the double Ctreatment groups (P>0.05).6.Using multiple regression analysis: the total amount of time3C blood glucoseinsulin treated as independent variables, age, duration of disease, weight, waistcircumference, BMI, FPG, HbA1c, TC, TG, HDL-C, LDL-C, CRP, SBP, DBP, wearingan insulin pump on the first day average blood sugar, blood sugar wearing an insulinpump on the first day standard deviation,0hCP,2hCP, HOMA-β, HOMA-IR as thedependent variable, the first line of the linear correlation analysis results Show: Day ofinsulin and total weight, BMI, wearing an insulin pump section day average blood sugar related. Further line Stepwise regression analysis showed that: the total time of bloodglucose and insulin insulin pump worn on the first day was positively correlated withmean blood glucose (β=1.448, P <0.05).7.Using logistic regression analysis: all patients in the rate of blood glucose intogroups (blood glucose=1, glucose nonattainment=0) as independent variables, age,duration of disease, weight, waist circumference, BMI, FPG, HbA1c, TC, TG, HDL-C,LDL-C, CRP, SBP, DBP, wearing an insulin pump on the first day average blood sugar,blood sugar wearing an insulin pump on the first day standard deviation,0hCP,2hCP,HOMA-β, HOMA-IR as the dependent variable, the correlation analysis of theindependent variables: the rate of blood glucose was positively correlated with2hCP (β=0.359, P <0.05).Conclusion:1.3C program can significantly reduce blood sugar levels in type2diabetes, reduceblood sugar fluctuations, and the blood glucose ratio and the number of days are notsubject to standard course affected.2.Application3C programs with type2diabetes, blood glucose total time durationof insulin is not affected, and the first day of wearing an insulin pump higher meanblood glucose, the more insulin the total standard time.3.Compared with the double C program,3C program no advantage in terms ofefficacy, but can increase the safety of blood glucose control.4.Insulin pump type2diabetes,2hC peptide, the higher the rate of blood glucose.