The Analysis Of Related Factors For Hyponatremia After Transsphenoidal Pituitary Adenoma Ectomy

Objectives： To analysis gender, age, tumor size, immunohistochemical resultsafter operation, extent of resection, tumor invasion, with or without stroke, diabetesinsipidus and other conditions in the analysis to explore the influence factors ofhyponatremia complicated with pituitary adenoma after trans-sphenoid operation. Andsumme up the law to provide a theoretical basis for the prevention and treatment of thecomplication in clinical practice.Materials and methods:96complete cases of pituitary adenoma patientsunderwent trans-sphenoid operation from the First Affiliated Hospital of Dalian MedicalUniversity from December2012to March2014were collected. We selected eightindicators of gender, age, tumor size, immunohistochemical results after operation,extent of resection, tumor invasion, with or without stroke and diabetes insipidus asinfluence factors, and established logistic regression using data spss13.0software forstatistical analysis, p<0.05was set as criteria forthesignificantdifference.ResultsAmong96cases of patients,42cases suffered hyponatremia complicated withpituitary adenoma after trans-sphenoid operation(43.75%of incidence),19cases of mildhyponatremia (45.24%);21cases of moderate hyponatremia (50%);2cases of severehyponatremia (4.76%).Clinical manifestations of28cases among the42cases were anorexia, fatigue, listlessness, drowsiness, nausea, vomiting, dizziness, headache, etc.While the other14patients complained of no discomfort.All patients were given asalt-rich diet, and water supply was restricted depending on the situation. patients withmoderate to severe hyponatremia were given3%sodium chloride intravenous solutionslowly. The prognosis of all cases is good, and no serious complications occurred duringthe treatment.ConclusionThe age, tumor size, pathologic characteristics of the tumor are therelevant factors for incidence of hyponatremia after the TSS. However, sex, extent ofresection, whether or not breakthrough saddle compartment, with or without stroke,diabetes insipidus, were irrelevant with the incidence of postoperative hyponatremiaafter the TSS.