Experience In Prescription Research Of Professor Wen Zhen Liang.S Treatment For Polycystic Ovary Syndrom Based On Data Mining

Objective:To explore in depth and inherit Wenzhen Liang’s clinical experience in polycystic ovary syndrome through applying the advanced data mining technology, in order to promote the dialectical thinking as well as the pattern of prescriptions to be widely applied in clinic.Method:To input the first and follow-up diagonosis data by western doctors on patients of Polycystic Ovary Syndrome (PCOS) into the medical record collection system provided by the information center of the First Hospital Affilliated to Anhui University of Chinese Medicine, statistically analyze all up-to-standard clinical data through data mining methods, such as frequency analysis, scale-free network analysis, association rules analysis, so on and so forth, and finally discuss the dialectical thinking as well as the pattern of prescriptions on PCOS through analyzing the results of data mining and combining with Professor Liangs’ experience in treatment.Result:By software analysis, the main symptoms of PCOS are menstrual cycle delay, red menstruation, menstrual blood clots, lumbago, irritable, little menstruation, thin tongue coating, pale tongue, little leucorrhea, premenstrual breast swelling, facial acne, poor sleep, loose stool. The main types of syndrome are deficiency of kidney and stagnation of phlegm, deficiency of kidney and stasis of blood, and block phlegm, The core prescriptions of PCOS are Angelica, Medlar, Codonopsis, Rehmannia Glutinosa Libosch, Atractylodes, Dodder. The common couplet medicine are Rehmannia Glutinosa Libosch, Yam; White Mustard, Arisaema Cum Bile; Radix Trichosanthis, Chinaberry Fruit; Herba Lycopi, Cyathula Officinalis; Codonopsis, Dodder; Atractylodes, Codonopsis; Atractylodes, Dodder; Rehmannia, Medlar; Rehmannia, Dodder; Arisaema Cum Bile, White Mustard; Radix Trichosanthis, Medlar. Here is the relationship of drugs and symptoms about PCOS. The common drugs for menstrual cycle delay:Angelica, Medlar, Dodder, Codonopsis, Atractylodes, Rehmannia Glutinosa Libosch, Arisaema Cum Bile, Yam, Herba Artemisiae Capillariae, Radix Trichosanthis, Salvia Miltiorrhiza, Chinaberry Fruit, Astragalus Mongholicus. For abdominal pain:Angelica, Medlar, Codonopsis, Rehmannia Glutinosa Libosch, Atractylodes, Yam. For mild lumbago: Angelica, Medlar, Atractylodes, Codonopsis, Dodder, Rehmannia Glutinosa Libosch, Herba Artemisiae Capillariae, Astragalus Mongholicus, Yam. For menstrual blood clots:Medlar, Angelica, Dodder, Codonopsis, Rehmannia Glutinosa Libosch, Herba Artemisiae Capillariae, Atractylodes. For less menstruation: Codonopsis, Medlar, Angelica, Dodder, Atractylodes, Rehmannia Glutinosa Libosch, Yam. For pale tongue:Dodder, Medlar, Angelica, Codonopsis, Herba Lycopi, Cyathula Officinalis. For LH/FSH>2:Dodder, Angelica, Codonopsis, Medlar, Herba Artemisiae Capillariae, Herba Artemisiae Capillariae, Arisaema Cum Bile, Rehmannia Glutinosa Libosch, Yam, Salvia Miltiorrhiza, Astragalus Mongholicus, Chinaberry Fruit,China root, Atractylodes, Citrus.Conclusion:Through the mining study, it proves that the kidney deficiency is the basic pathogenesis of PCOS accompanied by stagnation of phlegm and blocking phlegm. The medicine for tonifying kidney, reducing phlegm, invigorating blood, should be used mainly for kidney-reinforcing and in conjunction with phlegm supplementation. It is flexible in clinical application. The core prescription, couplet medicine as well as the drugs used by LH/FSH>2which are explored in this paper provide some clues for clinical or basic research, but the effect mechanism needs to be verified in further experimental study. Our data mining system is a practical aid to analysis of the rule of medication and particularly as a vehicle to explore famous traditional Chinese medicine doctors’experience in prescription.