Curative Effect Observation On Combined Application Of Artesunate And Azithromycin To Treat Malaria

Objective:1. Curative effect of treating malaria with artesunate and Azithromycin combined;2. Curative effect was observed for the standard vivax malaria (Plasmodium falciparum)treatment of local vivax malaria (Plasmodium falciparum);3. Curative effect treatment of malaria with artesunate and Azithromycincombinedecompared with standard vivax malaria, Plasmodium falciparum malaria therapy;Methods:In the western area of Yunnan Province, China Myanmar border in Laiza andRuili Island town two places to set up observation points, the main observe artesunateand Azithromycin combined with killing human malaria parasite. To smear microscopyconfirmed the single infection of Plasmodium vivax and falciparum malaria patients instrict accordance with the screening conditions selected.Plasmodium vivax malaria were randomly divided into A group (artesunate andazithromycin in the observation group) and group B (The standard chlorine primarytreatment for8days), Falciparum malaria were randomly divided into C group(artesunate and azithromycin in the observation group) and group D (dihydroartemisininpiperaquine phosphate group). Accordance with the order of patients1:1random numberinto the group, A group and C group with3days of treatment with artesunate andazithromycin,B group of3days of primaquine phosphate8days treatment withChloroquine Phosphate Tablets, group D with Dihydroartemisinin and PiperaquinePhosphate Tablets3days of treatment. Plasmodium vivax malaria medication after24,48h, Observation/count Plasmodium reduction rate, clinical cure rate of1kW, lastMarch, to observe the cure rate; And observe the patient body temperature returned tonormal time. Falciparum malaria were observed after24,48h, observe/countPlasmodium reduction rate, clinical cure rate of1kw, the cure rate of28d. All patientswere detected after the treatment of24h and48h heart/kidney/liver function andadverse reaction. The results were analyzed by SPSS16.0software,comprehensiveevaluation of the effectiveness and safety of artesunateand Azithromycincombined with. Results:Vivaxmalaria Agroup (artesunate and azithromycin) a total of52cases, theaverage temperature38.5±0.11℃, the mean parasite density5320/ul before taking.Complete a full course of treatment (3days) in52cases, effective in52cases, efficiencyof100%; clinical observation of51cases of7d,1cases of withdrawal. The averagecooling time of31.69±1.73h, Mean parasite clearance time was30.31±1.71h. Theclinical cure rate100%,282d,the cure rate was78.3%(36/46),602d, the cure ratewas70.7%(29/41),902d, the cure rate was68.4%(26/38). vivax malaria B group atotal of38patients, the average temperature38.9±0.13℃, before taking the meanparasite density4507/ul before taking. All courses of treatment (3days ChloroquinePhosphate Tablets, primaquine phosphate8days) in39cases, Effective in39cases,efficiency of100%, The average cooling time of32.4±2.02h,30.82±1.98h meanparasite clearance time, clinical cure in39cases, the clinical cure rate100%.282d,the cure rate was97.4%(38/39),602d, the cure rate was89.7%(35/39),902d, thecure rate was87.2%(34/39). A, B group compared to the average defervescence time,the parasite clearance time, no significant difference (P>0.01). A, B between the twogroups for282d,602d,902d, the cure rate, the difference was statisticallysignificant (P<0.05).Falciparum malaria C group (artesunate and azithromycin) a total of23cases, theaverage temperature39±0.19℃, the mean parasite density19462/ul before taking.Complete a full course of treatment (artesunate and Azithromycin combined with3days)in23cases, The efficiency of95.7%(22/23), the average cooling time of42.57±3.74h,Mean parasite clearance time was41.13±3.63h, Complete28of follow-up in20cases,13cases were cured, the cure rate was65%(13/20). Falciparum malaria D group(dihydroartemisinin piperaquine) a total of22cases, before taking the averagetemperature38.6±0.2℃, before taking the mean parasite density14923/ul, Complete afull course of treatment (Dihydroartemisinin and Piperaquine Phosphate Tablets3days)in22cases, efficiency of100%, The average cooling time of37.09±4.67h,the parasiteclearance time was35.55±4.66h. Complete28days of follow-up of17cases were cured,the cure rate of100%. C,D group compared to the average defervescence time, theparasite clearance time, no significant difference (P>0.01). C,D between the two groups28days cure rate were significant (P<0.05).4groups of patients on the drug had bettertolerance, Individual patient occurrence diarrhoea, nausea,abdominal pain and othersymptoms in the medication process, were mild and self limiting.Conclusion:1. Standard chloride/primaquine8day therapy to treat the local vivax is safe andeffective,3months curative rate was87.1%; Compared withthe standard therapy for thetreatment of vivax malaria, the combined application of artesunate and azithromycin inthe treatment of vivax malariahas the advantage of quick and fewer adverse reactions,etc., but vivax malaria cure rate lower than the former 2. Standard double hydrogen artemisinin piperaquinepiece therapy to treat localfalciparum is safe and effective,the cure rate of28d100%;Compared with thestandardtherapy, the combined application of artesunate and azithromycinare similarinthe short-termefficacy and adverse reaction in the treatment ofFalciparum malaria,butthe cure rate lowerthan the former.