The Clinical Research On The Relationship Between Plasma B-type Natriuretic Peptide Levels And The Therapy Of Early Intervention In Acute Myocardial Infarction Patiants

ObjectiveTo study the concentration level of B-type natriuretic peptide(BNP) of the patient with acute myocardial infarction(AMI),and then to discuss the relationship between the levels of BNP and the development and recent prognosis of disease after early revascularization with AMI.Methods1.80patients with AMI for the first time were selected as AMI group according the standards. And44healthy people matched as the control group.2. The levels of serum BNP were measured at admission,, at1and7days after admission,according to the status of infarction related artery within6hours whom were devided into patency group and occluded group. And echocardiography was performed with7days after admission in all patient.All patients had been followed-up for24monthes,recorded clinical terminal events.Results1.The median concentration of BNP with AMI was220.7±60.8pg/ml and63.8±32.1pg/ml in patients of the control group, the BNP levels in patients with AMI were significantly higher than patients in control group(P<0.01)2. The levels of BNP at admission were no difference in the two groups of AMI,but at1week the levels of occluded group were significantly higher(P<0.01).3. The levels of BNP in three points had positive correlation with LVEDVI、CK、 CK-MB、cTnI,but had negative correlaton with LVEF (P<0.05).4. BNP and the status of infarction related artery within6hours were the independent risk factors for predicting the infaust of cardial adverse events,but by multiple factors cox regression analysis,that levels of BNP2may prognose the infaust of cardial adverse events in2years after AMI.5. The cut-off point value of BNP determined according to ROC curve was340pg/ml and the sensitivity was77.8%,the specificity was74.5%.Conclusion1.The level of BNP significantly increased in the infaust prognosis in the patients of acute myocardial infarction.2. The mean value of serum BNP increased in the AMI patients,which has positive correlation with LVEDVI while has negative correlation with LVEF.Serum BNP can be decreased in condition of dredging IRA.3. The level of BNP was the independent risk factors for predicting the infaust of cardial adverse events in2years after AMI.