The Study Of The Mechanism Research Of The Treatment Which The Jianxinpinglvwan Treat Coronary Heart Disease With Ventricular Premature Beat

Background:Ventricular premature beat (VPBs) is a kind of the most common arrhythmias. The pathogenesis of ventricular extrasystole mainly includes the following kinds:reciprocal excitation、Trigger events、Exciting conduction of ectopic pacemaker enhancing. Coronary heart disease (coronary arteriosclerotic cardiopaathy, CHD) is the most common and frequent of Cardiovascular diseases. It pathology and physiology characteristic of the CHD are lipid and composite deposition, aggregation of sugar, Fibrous tissue hyperplasia and calcification and the buildup of plaque, So much so that the gradual degeneration of the arterial intima and the membrane, then hemorrhage secondary plaque, plaque rupture, and the local thrombosis are formating. But the commom of kind is Arrhythmia. And it is familiar with ventricular extrasystole. At present, GHD the cause of the ventricular extrasystole is still unclear. In recent years, Inflammatory cytokines (including: C-reactive protein CRP)、elevated blood fat、increased blood pressure、 high homocysteine impact CHD and VPBs’happening and progressing are found in the more research. The two methods are thinked the treatment strategies of CHD and VBPs. One way include expansing blood vessels、falling blood pressure、adjusting the biood fa、resistancing platelet collected、stabling plaque and oral Anti-arrhythmic drugs ect. another is doing the surgery of heart to restore the conduction of heart. VBPs is belong to the category of "Heart palpitations" in Traditional Chinese medicine. The conventional remedies of it have the following ways:tonify the spleen、invigorate the circulation of blood、warm the yang、soothe the nerves. The Jian xin ping lv wan is the compound preparation, rooted in experience which is summaried Dengtietao professor cure the patients who were getting Cardiovascular diseases. there elements have Radix pseudostellariae、Dwarf lilyturf、 Astragalus mongholicus、amboo shavings、reddish orange、Salvia miltiorrhiza、 notoginseng、pinellia、Hovenia dulcis、Zizyphus jujube benevolence. they play a role of tonicing vital qi、reducing phlegm and yangxin. The composition of it is rigorous. They can strengthen the ischemic myocardial interstitial link43(Cx43) protein expression, improve myocardial ischemia and inhibit the expression of water channel protein (AQP4), reduce myocardial injury, to strengthen the expression of myocardial cells, adjust the electrophysiological activity of normal myocardium, and reduce mortality and the incidence of arrhythmia, and improve heart function, therefore, the treatment of arrhythmia and the curative effect is certain.. So this agent is not only improve the clinical curative effect about CHD and VBPs, but also extended the time of recurrence or add this disease. There is no adverse reactions is the most important thing.Objective:This study observe the clinical efficacy which the Jian xin ping lv wan remedy CHD and VBPs and discuss the mechanism and advantage of it. they provide a new train of thought about cure heart diseases More in-depth.Methods:TThis research use a stochasticed、contrast way. The method divided into two groups:one is used to tested(incled30peole),another is contrasted(incled25peole). these people cannot take the drug which contains impacted heart rate、blood fat in the first three weeks of doing the experiments. Control group using oral aspirin enteric-coated metformin hydrochloride (100mg/producer:bayer pharmaceutical group grain) Every half an hour after dinner1100mg/day, isosorbide mononitrate zyban (producer: astrazeneca pharmaceutical co., LTD.60mg/grain) Half an hour after breakfast60mg1time/day, atorvastatin calcium tablet (20mg/producer: Pfizer pharmaceutical co., LTD. Grain) Every half an hour after dinner20mg1time/day. The experimental group take the Jian xin ping lv wan On the basis of the contrast group, and eat it6grams each time, everyday one body eat3times. this drug is offered by the Traditional Chinese medicine hospital of Shenzhenshi (Batch number:120308). We can see the patient’main symptoms(heart palpitations、chest tightness、shortness of breath、weak、 insomnia、dizzy、diet、tongue、pulse)、signs、blood fat、CRP、homocysteine、 electrocardiogram and UCG(the movement of the ventricular wall and the size of the ventricular wall).Results:1、We ask for the result of the clinical curative effect after patients with medication six month. there are meaning with the contrast group and the experimental group in statistical. And the result of the experimental group Better than the contrast group(P<0.05).2、We ask for the dynamic electrocardiogram change after patients with medication six month, there are meaning with the contrast group and the experimental group in statistical. And the result of the experimental group Better than the contrast group(P<0.05).3、There was no difference about blood fat before experiment with the contrast group and the experimental group (P>0.05). After medication six month, there are obvious statistical meaning about blood fat with two grops (P<0.05). and the experimental group is better than the effect of control group(P<0.05).4、here was no difference with CRP before experiment between the contrast group and the experimental group(P>0.05). After medication six month, There are statistically significant with two grops(P<0.05). and the experimental group is better than the effect of control group(P<0.05).5、It makes no sense about homocysteine before experiment with the contrast group and the experimental group(P>0.05). After medication six month, there are obvious statistical meaning with two grops(P<0.05). and the experimental group is better than the effect of control group(P<0.05).Conclusion:1、The effect of medication which treat CHD and VBPs with cooperate with the Jian xin ping lv wan is better than that of Western medicine treatment purely. And it may improve the clinical symptoms, sign, laboratory indicators abut CHD and VBPs. So its curative effect is sure.2、The Jian xin ping lv wan can reduce the level of blood fat, CRP, homocysteine, and decrease the number of VBPs attacked.3、The Jianxinpinglvwan is no adverse reaction, it is safe and effective drug for the treatment of coronary heart disease with ventricular premature beat.