Study On Clinical Curative Effect And The Effect On Pulmonary Function And Immune Function Of Qingrejiedufuzheng Decoction On Patients With AECOPD

Objective: To observe the clinical efficacy of Qingrejiedufuzheng Decoction on patients withAECOPD and its effect on pulmonary function and immune function, and to evaluateits safety.Methods: Choose72patients with AECOPD that meet the inclusion criteria. These patientswere randomly divided into treatment group and control group,36cases in each group.5caseswere losed in the process of observation. Finally, the number of cases was67,33cases in thetreatment group,34cases in the control group. The treatments of two groups take a paralleldesign. The control group was given routine treatment of Western medicine. The treatmentgroup was given a dose of Qingrejiedufuzheng Decoction every day, besides the same treatmentof control group. The course of treatment was14days. At the beginning of treatment and at theend of observation records syndrome integral, detect and record the data into the testingitems of observation.Results:(1) Patients in the treatment group after treatment, symptom scores decreased betterthan that in the control group (P<0.05), the efficiency rate and control rate of the treatmentgroup was81.82%, more than52.94%of control group (P<0.05);(2) Patients in the treatmentgroup after treatment, the efficiency rate and control rate of cough, phlegm, wheezing, shortnessof breath, fatigue, sweating, thirst, lungs signs, individual symptoms and signs of significant wasbetter than the control group(P<0.05);(3) After treatment, two group’s bloodroutine indexes(WBC, NE%, LY%) improvement were better than before treatment(P<0.05),but here was no marked difference between treatment group and control group(P>0.05);(4)After treatment, two group’s lung function (FVC, FEV1, FEV1%, FEV1/FVC) were significantly improved than before treatment (P<0.05, P<0.01), and Pulmonary function FVC,FEV1, FEV1%in treatment group were better than that in the control group s (P>0.05);(5)Patients in the treatment group aftertreatment, T lymphocyte subsets CD3+had nosignificant change (P>0.05), but CD4+, CD4+/CD8+compared with those beforetreatment were significantly increased (P<0.01), CD8+significantly decreased (P<0.05).The T lymphocyte subsets of control group patients after treatment had no significantchanges (P>0.05);(6) Two groups of patients before and after treatment to observe the safetyof the project had no significant difference, and the occurrence of adverse reaction in the twogroups during treatment showed no significant difference (P>0.05).Conclusion: Qingrejiedufuzheng Decoction on AECOPD (syndrome of phlegm-heatobstructing lung combined deficiency of both qi and yin) has good clinical efficacyand safety. It can improve significantly the efficiency rate and control rate of clinicaltreatment, and both the pulmonary function and immune function showed a positiveinfluence, this Qingrejiedufuzheng Decoction has a high clinical practical value.