The Investigation Of Glucose And Lipid Metabolic Abnormality In School-age Children And Adolescents Surifng Obesity

ObjectivesTo preliminarily understand the situation of glucose and lipid metabolism andliver， heart and other target organs in obese children and adolescents， which mighthelp take early intervention to prevent serious complications.MethodsThe children and adolescents were chosen in Zhengzhou People’s Hospital whoadmitted to the child clinic from June2012to June2013.They were divided into threegroups， including obeisity group， overweight group and the normal group. Thefasting venous blood was taken， and the following indices were detected: fastingplasma glucose (FPG)， triglycerides (TG)， total cholesterol (TC)， alanineaminotransferase (ALT)， fasting insulin (FINS) and other indicators， and insulinresistance index (HOMA～IR) and pancreatic β～cell function value (HOMA～β)were calculated; oral glucose tolerance test (OGTT) and insulin release test were onlytested for the obese and overweight children.Children of the three groupsunderwent liver and heart ultrasound.ResultsCompared with the systolic blood pressure and the diastolic blood pressure ofthe control group， blood pressure in obese group were higher than the former (P<0.05)， the incidence of hypertension were0.00%(0/110) and9.8%(48/490) in theobese group and the control group， respectively. Compared with the control group，the levels of FBG， FINS， HOMA～IR and HOMA～β were elevated in the obesegroup (P<0.05); among all of the lipid metabolism～related indicators， comparedwith that of the control group， the HDL～C level was decreased， and the other three (TC， TG， LDL～C) were increased， and the differences were statisticallysignificant (P <0.05). The incidence of fatty liver varied according to the degree ofobesity (mild， moderate， severe)， and showed a positive correlation among thetwo， there was statistical significance between them (P<0.05)， and the incidence ofobesity and fatty liver showed that the incidence of fatty liver increased with obesitydegree (2=12.97，P <0.05). For the obese children，there were268cases who werefat thickening， the average thickness was（3.369±0.099）mm， compared with thecontrol group， the difference was statistically significant (P<0.001).ConclusionCompared with children of normal weight，the risk of hypertension and the rateof abnormal glucose metabolism in obese children were elevated， abnormal glucosemetabolism abnormalities (including impaired fasting glucose， insulin resistance，impaired glucose tolerance， hyperinsulinemia and β～cell function to minimize，etc.) can occur in mild obesity. In addition， dyslipidemia in obese children behavemore obviously， fatty liver can occur simultaneously， the incidence of fatty livervaried due to obesity， there was a positive correlation between the two， the10～year～old obese children were more susceptible to fatty liver. Compared with normalweight children， left ventricular hypertrophy and thickening of pericardial fat inobese children displayed obviously， especially.