â… The Clinical Analysis Of11Cases Primary Malignant Melanoma Of The Female Genital Tractâ…¡ Menopause Symptoms And Treatment After Surgical Menopause

Objective: To investigate the clinical and pathological features,diagnosis, treatment, treatment progress of the primary malignantmelanoma of the female genital tract, and to reduce misdiagnosis andimprove the prognosis.Methods: From May2006to August2013，we collected the clinicaland pathological data of11cases the primary malignant melanoma of thefemale genital tract who were treated in f the first hospital affiliated tochongqing medical university and reviewed the related literature publishedin China and abroad.The specimens by biopsy or operation in those caseswere carried out pathological exam of HE and immunohistochemicalstaining，such as Melan-A，HMB-45，S-100，Vimemtin，CK.Results:1.The age patients were between31-67years old.3casesfrom vulva3,6cases from vaginal,1case from cervical,1case fromovarian.6cases of them are postmenopausal.2. The positive rate of Melan–A is100%, the positive rate of HMB–45is100%, the positive rate ofS-100is100%, the positive rate of Vimemtin is33.33%, the negative rateof CK is57.14%.3. According to patients’ conditions and pathologic stage, surgical resection and followed by combined chemotherapy withDTIC．Conclusion: Because the clinical fetures of the primary malignantmelanoma of the female genital tract are nonspecific, it is easy to bemisdiagnosis, as Melan-A is specific and sensitive, HMB-45is specific butpoorly sensitive. S-100is sensitive but poorly specific, athologicalhistology diagnosis combination of multiple immunohistochemicaldetection is helpful the diagnose；The primary treatment of MM is surgicalresection, followed by chemotherapy, radiotherapy, biological treatment orgene therapy. There is more and more surgery menopausal women. Surgicalmenopause refers to cause ovarian function lost followed sugery.. surgerymenopausal women mainly involved who undergoing bilateraloophorectomy because of endometrial cancer, cervical cancer, ovariancancer, ovarian endometriosis, uterine fibroids and so on. The second arewho undergoing Prophylactic oophorectomy should be disease ofdepartment of gynaecology such as therapeutic ovariotomy.H-P-O shaft of women balance disorders, and they affected bycomplex factors such as psychological, social. there may be a series of ofmenopausal symptoms. After Surgical menopause,estrogen plummeted, itmakes women under more serious menopausal symptoms.MHT is the most effective way to reduce menopausal symptoms, suchas vasomotor symptoms and urogenital atrophy, and it is also the first-linetreatment for preventing bone mass and osteoporosis. The security of MHTis associated with age. Healthy women whose age <60should not worryabout it. WHI and other studies confirmed that the effects of HRT on breastcancer, mainly due to progesterone.So we should reduced dose of progesterone to minimum one.