Effects Of Controlled Hypotension On Post Operative Cognitive Function In Patients With Hypertension During The Surgery

Objective To investigate the effects of controlled hypotension on congnitive function after endoscopic sinus surgery in hypertensive patientsMethods Forty ASA I or II patients, younger than65years old, weighing50-80kg undergoing endoscopic sinus surgery were randomly assigned to2groups (n=20each): controlled group (group c), controlled hypotension group (group D). No controlled hypotension did on group C, in group D controlled hypotension was induced and maintained with pumped Sodium Nitroprusside at1-5ug.kg-1.min-1. Mean arterial pressure (MAP) was maintained at about70%of baseline. The congnitive function was assessed1day before surgery(baseline) and at6h、24h、48h and72h after surgery using minimented state examination (MMSE) and the Montreal Cognitive Assessment(MoCA). Results No significantly decreased at MMSE scores and MoCA scores after surgery from6h to72h in both groups. The MMSE scores were significantly increased after surgery at48h and72h, there was no significant difference in MMSE scores between the2groups (C and D). The MoCA scores were significantly increased after surgery at24h、48h and72h,and The MoCA scores in group D after surgery at24h、48h and72h were obviously lower than those in group C.Conclusion Controlled hypotension during endoscopic sinus surgery may not increase the incidence of postoperative cognitive dysfunction in unelderly hypertensive patients.