| Objective:This study aimed to investigate the effects of recombinant human brain natriuretic peptide in heart rate variabilityand functions ofcardiac in patients with chronic heart failure.Methods:Our52hospitalized patients with CHF since from January2013to December2013, which contained27males and25females aged from49to87(means67.08+11.45). These cases were randomly divided into treatment groupscontaining26patients and control groups which were also26cases. Both groups were given conventional treatment with anti-heart failure drugs(including statins, diuretics, ACEI, ARB, and vasodilator drugs). Besides of a basictreatment with anti-heart failure drugs, treatment groupswere also injectedwith recombinant human brain natriuretic peptide at the same time. First of all, the projectile intravenousimpactionswere given with1.5ug/kg, followed by pumping a continuous intravenous infusionwith a speed of0.0075ug/kg/min for72hours. A24hoursexamination of ambulatory ECG, were continuous used for one week respectively to analyze the time-domainsof heart rate power spectrum during drug treatment or one week before. And the changes of all HRV indexesandthe improvement were comparingbetween treatment groups and controls during injection of drugs. Blood levels of BNP in all patients were tested inthe groups of both pre-therapies and post-treatments. The examinationsof12-lead ECGwere used in treatment groups before drugs injection, meanwhile heart rateswere recorded. The ECGand heart rateswere recordedonce againafter pumping drugs for72hours. Then we contrastedthe heart rates betweentreatment groups during drugs stimulations. Blood Potassium values were detected and recorded in treatment groupsbefore drugs given. The tests and records which were comparing with before, were repeated after a thoroughpumping the drugs. Results:The values of SDNN, SDANNand PNN50were all increased significantly after therapy in treatment groups (p<0.05). There were no obvious differences between all HRV indexes in control groupsduring drugs injection (p>0.05). Moreover, the values of SDNN, SDANN and PNN50in HRVIndexes were all increased obviouslyafter treatments between treatment groups and controls (p<0.05). BNP levels in the treatment groupsdecreased significantlycomparing with that before hospitalization(P<0.05).The heart rates decreased obviously and urine volumes increased significantlyafter injection of drugs (P<0.001). And there was no statistical significance of blood Potassium valueunder the effects of drugs (P>0.05).Conclusion:Improvement the HRV indexes in patients with chronic heart failure is one of the mechanisms involved in the process of rhBNP resisting to heart failure. |
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