The Study Of Catheter-directed Thrombolysis With Additional Balloon Dilatation For Iliofemoral Deep Venous Thrombosis

Purpose： Catheter-directed thrombolysis (CDT) is effective for acuteiliofemoral deep venous thrombosis (DVT),but CDT remains partially effectivefor subacute DVT. The aim of this study was to conduct a trial to compare CDTalone with CDT with additional balloon dilatation for the treatment of iliofemoralDVT.Methods：The study was to conduct a prospective randomized controlledsingle-centre clinical trial which was performed between September2010andMarch2013. Iliofemoral DVT patients were randomly assigned to CDT (controlgroup) and CDT with additional balloon dilatation (intervention group). TheVillalta score was observed between the intervention group and the control group.Results：In acute patients,no significant difference for mean Villalta scorewas observed between the intervention group and the control group from1month(6.76±4.21,6.81±4.23；P=0.94) to12months (4.71±3.26，4.99±3.40；P=0.93). However, The mean Villalta scores in the subacute group showedsignificant differences between the intervention group and the control group from 1month (6.79±4.23,8.28±5.03；P=0.02) to12months (4.81±3.30,6.23±3.98；P=0.01).Conclusion：Subacute iliofemoral DVT patients lacking effective therapyduring acute phase, might receive more benefits from CDT with additional balloondilatation.