The Expression And Clinical Significance Of FKBP51in Bladder Urothelial Cancer

OBJECTIVE To investigate the expression of FKBP51(FK506Binding Protein51) in human bladder urothelial cancer, and analyze its relationship with clinical data and pathological features of bladder urothelial carcinoma, expecting to provide theoretical basis for early bladder cancer diagnosis and assessment of the degree-of malignancy.METHODS A total of65specimens of bladder urothelial cancer, from complete radical cystectomy and confirmed by the pathologist, were obtained from the archives of the Department of Pathology, Central South University Xiangya No.2Hosptial, hunan China between January2011and December2013, Subjects were49man and16women with a mean age of64.2years old and median age66years old (rang46.0-80.0),39subjects are older than60years,the others are younger than60years. The size of tumor no more than3cm is23, and42more than3cm. According to2004WHO histological grade, the tumors comprised41Low-grade (well differentiation) papillary urothelial carcinoma, and24high-grade (poor differentiation) papillary urothelial carcinoma. According to TNM of UICC (the7th Edition2009) classification, the tumors comprised47non-muscle invasive bladder urothelial carcinoma (Tis, Ta, T1)and18muscle invasive bladder urothelial carcinoma(T2-T4). According to whether there is lymph node metastasis,49subjects are lymphatic metastasis,the other16subjects are not lymphatic metastasis. At the same time we collect15cases of normal bladder tissue as control group. We detect the expression of FKBP51protein in specimens of the study via immunohistochemistry, and analyze the relationship between their expression levels with clinical data and pathological features of bladder urothelial carcinoma by Statistical Methods.RESULTS FKBP51protein expresses in all of specimens include bladder cancer tissue and normal tissue, but the expression levels in bladder urothelial cancer are much higher than that in normal bladder tissue(p<0.01), and its expression levels are not related with gender, age and tumor size(p>0.05), However,there is correlation of FKBP51protein expression levels with clinical stages (p<0.05), pathological grade (p<0.05), lymphatic metastasis(p<0.05).CONCLSION1.The expression of FKBP51protein in normal bladder tissues are low, while that in bladder urothelial carcinoma tissues are high, This differential expression suggest that FKBP51possibly relate to the generation of bladder urothelial carcinoma, and have a role in early diagnosis of bladder urothelial carcinoma.2.The expression levels of FKBP51protein in bladder urothelial carcinoma relate to its clinical stages and pathological grades, which implies FKBP51protein as a biomarker of Assessment of the degree of malignancy of bladder urothelial carcinoma, but specific specificity and sensitivity need further research.