The Correlation Analysis Of Resting Heart Rate And Related Risk Factors In Coronary Heart Disease With Extent Of Coronary Artery Lesion

Objectives:We tried to explore the relationship between patients’ resting heart rate and the occurrence,development and severity of coronary’ heart disease, the relationship between resting heart rate and risk factors of coronary heart disease such as serum lipids, fibrinogen, uric acid and so on. Thus, we can provide more evidence for the treatment of coronary’ heart disease, especially the secondary prevention,and improve the long-term prognosis.Objects and methods:It’s a retrospective analysis of patients admitted into the Department of Cardiology of Xiangya Hospital from January1st,2012to December31st,2013and diagnosed with coronary heart disease.We reviewed these patients’Gensini integral,resting heart rate and risk factors to know the effects of sex acting on resting heart rate with coronary heart disease. There were1344objects.Results:(1)Resting heart rate of the CHD group is faster than the non CHD group, both the stable angina group and unstable angina group are slower than the acute myocardial infarction group, P<0.05; there is no statistical significance between stable angina pectoris group and unstable angina group, P>0.05.(2)Results of resting heart rate and Gensini integral Pearson linear correlation analysis is r=0.128, P<0.001.(3) Comparison of resting heart rate with Gensini integral in two groups shows resting heart rate of<70bpm group is less than>70bpm group (P<0.05).(4)Multiple linear regression analysis shows that the correlation between multiple variables and Gensini integral in CHD group:age (β=0.767, P=0.002), diabetes mellitus (β=10.027,P=0.047), smoking (β=11.321, P=0.034), resting heart rate (β=0.599, P=0.005), high density lipoprotein (β=-31.892, P=0.002),fibrinogen((3=6.063, P=0.003), uric acid (β=0.047, P=0.05).(5)Multiple linear regression analysis shows that the correlation between the variables and resting heart rate in CHD group:age (β=-0.179, P<0.001), diabetes (β=1.913, P=0.033), smoking (β=2.278, P=0.016), cholesterol (β=2.377, P=0.017), low density lipoprotein ((3=-2.194, P=0.027), fibrinogen (β=0.725,.P=0.043), high sensitive C reactive protein (β=0.092, P=0.002).(6)Comparison of resting heart rate and Gensini integral in different gender shows:female:r=0.162, P=0.004for bivariate Pearson correlation analysis;(3=0.966, P=0.038for multiple linear regression analysis. Male:r=0.114, P=0.001for bivariate Pearson correlation analysis; β=0.502, P=0.037for multiple linear regression analysis.Conclusions:(1) Severity of coronary artery stenosis is positively correlated with resting heart rate, age, diabetes, smoking, fibrinogen, uric acid, negatively correlated with high density lipoprotein. Resting heart rate was a risk factor of CHD.(2) Resting heart rate is positively correlated with diabetes, smoking, cholesterol, fibrinogen, high sensitive C reactive protein, negatively correlated with age, low density lipoprotein.(3) The correlation between resting heart rate and coronary heart disease is stronger in women than in men.