The Impact Of Bacterial Colonization/Infection On Clinical Manifestation And Prognosis Of Children With Bronchiolitis Induced By Respiratory Syncytial Virus

Objective: To investigate the impact of bacterialcolonization/infection of the respiratory tract on the clinicalmanifestations and the prognosis of bronchiolitis caused by respiratorysyncytial virus.Method:177RSV bronchiolitis children were enrolledretrospectively in Children’s Hospital, Chongqing Medical Universityfrom October2011to December2012in Respiratory ward1. All casesin accordance with the detection of bacteria were divided into twogroups: bacterial possitive group (B+) and bacterial negative group (B-)to study the effect of the bacterial colonization/infection on RSVbronchiolitis, to study Streptococcus pneumoniae （SP+）,Staphylococcus aureus（SA+）,Escherichia col（iE.coli+）,Haemophilusinfluenzae（HI+）,Haemophilus parainfluenzae（HPI+）, Moraxellacatarrhalis（MC+）colonization/infection on RSV bronchiolitis clinical manifestation and prognosis.Result:102cases had posstive bacterial detection in177RSVbronchiolitis children, accounting for57.63%of all cases. The severityof bronchiolitis between the positive bacterial detection and negativebacterial detection had no significant difference(P>0.05).The positiveand negative bacterial detection had no difference among theproportion of fever, duration of fever, duration of wheezing, length ofhospital stay, white blood cell count and absolute neutrophilcount(P>0.05).In terms of prognosis, there was no difference betweenpositive bacterial detection group and negative bacterial detectiongroup on recurrent wheezing and asthma(P>0.05).The proportion ofdiagnosed asthma with one year in SP+group and SP-group was22.2%and3.1%,and SP+group had higher risk of asthma than SP-group(P=0.05).Children developing to asthma in one year were morelikely to have Streptococcus pneumoniae colonization/infection(thepercentage was80%).Conclusion: Bacterial colonization/infection has no significantinfluence on the severity of bronchiolitis, duration of wheezing, lengthof hospital stay of children with RSV bronchiolitis.But Streptococcuspneumoniae colonization/infection may promote RSV bronchiolitis toasthma.