The Clinical Characteristics Of Sleep Disorders In Patients With Parkinson’s Disease (PD) And Analysis

Objective:To objectively analyze the manifestation of sleep disorder and clinical characteristics in patients with parkinson’s disease (PD) by polysomnogram(PSG) throughout a night and investigate the potential factors related to sleep disorders and probable pathogenesis in PD. Methods:Thirty three patients with PD and thirty three of age、BMI and sex etc.matched patients as the controls were monitored by polysomnographic (PSG) evaluation. Results:the occurrence rate of early awakening (4例,12.1%) fragmented sleep(25例,75.8%)and REM sleep without atonia(16例,48.5%) in PD patients group were remarkably increased than that in controls; There are not marked difference in S2%、S4%between the two groups, the percentage of awakening time occupy total sleep time、NREM%、S1%in PD patients group were remarkably increased than that in controls, S3%and REM%in PD patients group were remarkably decreased than that in controls; There are not statistics difference in sleep structure parameter between PD patients whose course of disease under2years group and controls.4、The percentage of awakening time occupy total sleep time、NREM%、S1%in PD patients whose course of disease more than2years group were remarkably increased and S3%、S4%and REM%remarkably decreased than that in controls; The percentage of awakening time occupy total sleep time in PD patients whose course of disease under2years group were remarkably increased and REM%remarkably decreased than that of PD patients whose course of disease more than2years group. Conclusion:1、The main clinical manifestations of PD patients with sleep disorder are early awakening、fragmented sleep and REM sleep without atonia.2、There is obvious sleep structure turbulence in PD patients:the time of light sleep become longer and deep sleep become thin and it is the disease、it’s course、age and medicine concuirented.3、Though disease’s course affected the sleep disorder obviously, in early stage sleep of PD patients was damaged.