Relationship Between TLR10Gene Polymorphism And Papillary Thyroid Carcinoma

Objective:To investigate the association between rs11466653, rsl1096956, rsl1096955gene polymorphisms in Toll-like receptor10(TLR10) gene and papillary thyroid carcinoma(PTC). Methods:To select86patients of papillary thyroid carcinoma as case group, to select84patients of nodular goiter as control group.Hardy-Weinberg equilibrium (HWE)analyze was performed for each single nucleotide polymorphism in the case and control groups to detect the group representation.Rs11466653, rs11096956and rsl1096955gene polymorphisms in TLR10gene were tested by using a direct sequencing method. Results:In the rs11096956T allele frequency is0.58in the case group and0.43in the control group, the difference has statistical significance,OR(95%CI)=1.81(1.18,2.78), P=0.007;The differences of genotype and allele distributions of the case and control group in the rs11466653and rs11096955have no statistical significance, P>0.05. The frequency of T-G-C haplotype is0.052in the case group and0.12in the control group, the difference has statistical significance, OR(95%CI)=0.41(0.18,0.92), P=0.027;The frequency of T-T-C haplotype is0.51in the case group and0.38in the control group, the difference has statistical significance,OR(95%CI)=1.71(1.11,2.6), P=0.015. Conclusion: In the patients with thyroid nodule,T allele of the rs11096956may be the susceptible factor of PTC; T-G-C haplotype may be the susceotibility marker of PTC,and T-T-C haplotype may be the protective marker of PTC.