The Study Of New Transdermal Patch And Its Transdermal Absorption

The aim of this paper was to investigate TPE-S as matrix for the transdermal patch. The factors of terpene resin, antioxidant, thickness of the patch and aging time were investigated through the Orthogonal test, the research got the results as followed:When the content of terpene resin was20%(w/w) and antioxidant-1010was0.2%(w/w) in the blank patch,its quick stick was15and inner cohesion was135minutes; There was small change for adhesive ability of the patch after64h accelerated aging experiment; The patch did not make any skin irritation in skin irritation experiment.UV method which was fast, simple, reproducible, accurate and reliable was used to determine solubility of VE in different solvents.40%Ethanol/Saline had been selected as the receptor medium of transdermal absorption in vitro.The effects of different categories of penetration enhancers on the transdermal absorption of VE were investigated by in vitro permeation studies. The co-enhancer (Azone/Oleic acid/1,2-PG:3/1/1) showed the greatest ability to enhance VE and its enhancing rate(ER) was7.7.This study prepared the monolithic adhesive dispersion type transdermal drug delivery system of VE with TPE-S and terpene resin. The results showed that20%VE(w/w),20%(w/w)terpene resin,6%(w/w) co-enhancer (Azone/oleic acid/1,2-propylene glycol:3/1/1) and the thickness of patches (0.6mm) maked a remarkable enhancement on VE. The VE patches were designed17mg/15cm2. The total accumulation Q was about16mg, which could meet human’s daily need (10-30mg/d). Accelerated aging experiment was done to determine the content of antioxidant1010in the patch was0.25%(w/w). This concentration could stop the patches being aged and prevent VE in the patch from being oxidized in a long time.Quality measures of the VE patch which included sample size and shape, homogeneity, detection of relative substances and release were investigated, the results showed that the patch were accorded with the pharmacopoeia requirement.The VE patch could constantly release drug and its transdermal absorption in vitro showed that the releasing curve of VE from patches was accorded with zero-order rules. The permeant behavior of the VE patch in vitro followed the Fick’s first diffusion law.