Serum Tenascin-C Concentrations And Postoperative Changes In Patients With Rheumatic Heart Disease

Objective:To investigate the expression of serum Tenascin-C concentrations in patients with rheumatic heart disease and postoperative changes, as well as the clinical value of being used as assessment of cardiac function in patients with rheumatic heart disease.Methods:Serum concentrations of Tenascin-C and NT-proBNP in patients with rheumatic heart disease were measured before surgery and postoperatively2hours,24hours,3days,5days and7days, respectively. And we tested serum Tenascin-C and NT-proBNP concentrations of healthy subjects as the control group.Results:Serum Tenascin-C concentrations in patients with rheumatic heart disease before surgery were significantly higher than the control group, the worse the cardiac function, the higher the concentrations (P<0.01). Bypass time had a significant influence on serum Tenascin-C concentrations on the early postoperative state (P<0.01). It elevated markedly and acutely to a peak level24hours after valve replacement surgery, then declined slowly,7days after surgery, serum Tenascin-C concentrations of patients with cardiac function class Ⅰ to Ⅱ are still higher than preoperative concentrations (P<0.05), while serum Tenascin-C concentrations of patients with cardiac function class Ⅲ to Ⅳ have been reduced to preoperative levels (P>0.05). Serum Tenascin-C concentrations were positively correlated with serum NT-proBNP concentrations (r=0.778, P<0.01).Conclusions:Tenascin-C can accurately reflect the cardiac function in patients with rheumatic heart disease. It is sensitive and correlated significantly with serum NT-proBNP concentrations. Thus we know that the Tenascin-C can be used as a clinical assessment of cardiac function. Moreover, compared to NT-proBNP, Tenascin-C may be a better indicator for long-term assessment of patients with cardiac function class Ⅲ to Ⅳ.