Risk Factors Associated With The Persistence Or Recurrence Of High-grade Cervical Intraepithelial Neoplasia After Loop Electrosurgical Excision Procedure

Objective:Through analyzing the basic information and pathological data and follow-up data of117women with confirming to be high-grade cervical intraepithelial neoplasia, we’ll explore the risk factors of residual and recurrent of high-grade cervical intraepithelial neoplasia (CIN) in the patients who were underwent cervical conization so that we hope to improve clinicians and high-risk groups’vigilance, slowing down or even stopping the progress from the high-grade intraepithelial neoplasia to invasive cervical cancer, and reducing the incidence and mortality of cervical cancer.Methods:We analysis retrospectively117patients who were visiting in the Department of Gynecology of Nanjing Drum Tower Hospital from2010to2012.All patients who underwent loop electrosurgical excision procedures (LEEP) owing to high-grade CIN were included. We complete the patients’ follow-up work after2years when they were underwent loop electrosurgical excision procedure and analysis the risk factors associated with residual or recurrent disease.Results:Risk factors associated with the persistence or recurrence of high-grade cervical intraepithelial neoplasia after loop electrosurgical excision contain deliveries, menopausal status, postoperative HPV-HC2positive result, margins, involving glands, lesions and cervical involvement. But the patient’s age, number of pregnancies, preoperative HPV positive result was not significantly related.Conclusion:Risk factors associated with the persistence or recurrence of high-grade cervical intraepithelial neoplasia after loop electrosurgical excision contain deliveries, menopausal status, postoperative HPV-HC2positive result, margins, involving glands, lesions and cervical involvement. Highly recognizing the risk factors of postoperative persistence or recurrent disease have significance in prevent the development of cervical intraepithelial neoplasia to invasive cervical cancer.