The Relation Between GDF-15,hs-CRP And Major Adverse Cardiovascular Events In ACS Patient

Objective：To observe the expression differences of GDF-15and hs-CRP inpatients with acute myocardial infarction, unstable angina, unstable angina andnon-CHD population.To investigate the relation between GDF-15,hs-CRP andmajor adverse cardiovascular events in ACS patient.Methods:127patients were selected in our study. Included55cases with acutemyocardial infarction (AMI),47cases with unstable angina (UA) and25cases withstable angina (SA). ALL the Acute coronary syndrome(ACS) patients treated withPCI.30normal coronary arteries were randomly selected as a control group. Clinical dataof four groups were recorded.Include age, sex, body mass index, hypertension, smoking,lipids, clinical medication and so on. The level of GDF-15and hs-CRP were determinedby ELIASA. Then We conducted a follow-up of90days in patients with ACS,andrecorded the major adverse cardiovascular events(MACE) occurred.Finally all the datawere analyzed.Results:1.The GDF-15levels was1515.19±462.29ng/L in AMI group,1160.63±271.60ng/L in UA group,844.84±182.69ng/L in SA group,590.90±150.08ng/Lin the control group,there was statistically significant difference between four groups(P <0.05);2. The hs-CRP levels was17.26±3.56mg/L in AMI group,8.78±3.32mg/L inUA group,2.23±0.84mg/L in SA group,1.71±0.56mg/L in the control group. Thelevel of hs-CRP of AMI group was significantly higher than UA group and SAgroup(P <0.05). The level of hs-CRP of UA group was significantly higher than SAgroup(P <0.05).SA group compared with control group had no significant differencein the level of hs-CRP(P>0.05)).3.The risk for MACE was increased in ACS patients with higher level of GDF-15and hs-CRP.4. The level of GDF-15in the event group was significantly higher than the no events group(P <0.05);The level of hs-CRP in the event group significantly higherthan the no events group.5.In patients with high level of GDF-15and high level of hs-CRP suggested a highrisk of MACE.6.GDF-15has positive correlation with the hs-CRP(r=0.415, P <0.01).Conclusion:1.The level of GDF-15is helpful for the diagnose of ACS.2.The level of GDF-15and hs-CRP in ACS patients can predict the occurrence ofMACE.Joint determination of GDF-15and hs-CRP can improve the accuracy ofprognosis in ACS patients.