The Applied Significance Of Carbon Nanoparticles In Surgery Of Papillary Thyroid Microcarcinoma

Objective To assess the applied significance of carbon nanoparticlesin surgery of papillary thyroid microcarcinoma (PTMC).Methods Between February2010and February2014,67patients whounderwent surgical treatment for PTMC at our hospital were randomlyallocated to the control group（n=34） and the carbon nanoparticles group（n=33）， receiving non-carbon nanoparticles trace and carbonnanoparticles trace respectively. All patients were received affected sideresection of thyroid plus neck dissection of the central compartments. Thenumber of lymph node dissection (LND)、 the rate of lymph nodemetastasis (LNM) in level VI、operation change and operative indexes（including operation time，intraoperative blood loss，postoperativehospital stay，and complication）were collected and compared between thetwo groups.Results There were197and152dissected lymph nodes in level VI inthe carbon nanoparticles group and the control group respectively. Theresults of postoperative pathology showed that the number of LND in level VI of the carbon nanoparticles group was much more than those of thecontrol group（5.97±3.92vs.4.44±2， P<0.05）. The rate of LNM in levelVI were63.64%in carbon nanoparticles group was much more than thosein the control group38.24%（P<0.05）.Because of LNM in level VI,21patients underwent total thyroidectomy in the carbon nanoparticles groupand12patients in the control group（P<0.05）.3patients occurredtemporary hypocalcemia in the carbon nanoparticles group and7patientsin the control group（P<0.05）. There were no significant differences in theoperation time，intraoperative blood loss，postoperative hospital stay，andother complication incidence between two groups（P>0.05）.Conclusions Carbon nanoparticles can improve the number of LNDin level VI of PTMC，which can make the staging of the tumor accuratelyand guide the scope of surgery and postoperative treatment. And it canprotect the parathyroid gland, avoiding hypoparathyroidism withoutincreasing（or prolonging） operation time， intraoperative blood loss，and postoperative hospital stay，and complication.