Functional Dyspepsia And Helicobacter Pylori

Functional dyspepsia is a common digestive disease, with features ofmany symptoms, long course, easily recur, decrease the quality life ofpatients seriously, and increase medical expenses rapidly. Up to now, it isstill not clear that the underlying factors involved in the occurrence offunctional dyspepsia. There are large amounts of data indicate that mostfunctional dyspepsia patients with the infection of helicobacter pylori, aftereradication of helicobacter pylori, indigestion symptom and prognosis ofFD patients can be improved significantly, and get higher cost-benefit ratio,which imply that the infection of helicobacter pylori may invovle in theoccurrence of functional dyspepsia, the underlying mechanisms include:1)Delayed gastric emptying: Gastric antral motility decreasedmarkedly, and gastroduodenal coordination dysfunction which related tothe gastroduodenal reflux under the circumstance of helicobacter pyloriinfection, which result in abnormal gastric emptying. The mechanisms arelikely to the expression of specific miRNAs (miR-1, miR-133) decreased,deacetylase-4and serum response factor increased in the gastric smooth muscle layer of functional dyspepsia patients with helicobacter pyloriinfection.2) Abnormal gastric acid secretion: Helicobacter pylori can result inthe gastric mucosal inflammation, and produced some cytokines, which isrelated to the abnormal gastric acid secretion of functional dyspepsiapatients with helicobacter pylori infection.3)Increased visceral sensitivity: The sensitivity of stomach increases,which may attribute to the increased expression of substance P andcalcitonin gene-related peptide in the gastric mucosa of functionaldyspepsia patients with helicobacter pylori infection.4)Influence of brain-gut axis: Helicobacter pylori could stimulategastric epithelial cells to release IL-8and other factors, which leads theinfiltration of mast cells in gastric body and antrum increased significantly,and finally influents brain-gut axis.