Risk Factors, Clinical Characteristics And CISS Classification Of Isolated Pontine Infarction And The Comparison With Anterior Circulation Infarction

Objective:To investigate the risk factors, clinical characteristics and classification of CISS of isolated pontine infarction. Methods:retrospective analysis were made in patients With acute Cerebral infarction in the department of neurology in our Hospital,2009January to2012December, isolated pontine infarction as case group, anterior circulation cerebral infarction as control group, to investigate the risk factors, clinical manifestations and CISS typing. Results:The risk factors of the two groups are different, persistent smokers (16.8%vs30.8%P=0.007), diabetes mellitus (53.6%vs34.1%, P=0.030), glycosylated hemoglobin (7.2±1.6vs6.6±1.7, P=0.006), low density lipoprotein (2.4±0.7vs2.7±0.9, P=0.003). Logistic regression analysis showed, lycosylated hemoglobin (OR1.183,95%CI1.007-1.389, P=0.041) are independent risk factors for isolated pontine infarction, persistent smokers (OR0.484,95%CI0.264-0.885, P=0.018),LDL-C(OR0.593,95%CI0.435-0.808, P=0.001) with the other; cilinical characteristics are also different between the groups:dizziness Or vertigo (46.3%vs21.6%, P=0.000), nausea and vomiting (26.3%vs7.8%, P=0.000), walking instability (29.5%vs10.2%P=0.000), diplopia (10.5%vsl.2%, P=0.000) tinnitus (6.3%vs0.3%, P=0.000), hearing loss (6.3%vs0.6%, P=0.001), blurred vision (7.4%vs2.1%, P=0.026), ataxia (38.9%vs28.1%, P=0.044), single limb sensory disturbance (7.4%vs2.4%, P=0.044), external ophthalmoplegia (8.4%vs1.5%, P=0.002), nystagmus (14.7%vsl.5%, P=0.000), aphasia (1.1%vs15.6%, p=0.000), cross sensory disturbance (2.1%vs0, P=0.049), facial paralysis (2.1%vs0, P,=0.049) cross dyskinesia (8.4%vs0, P,=0.000). logistic regression analysis showed, dizziness or vertigo (OR1.8271.024-3.259,95%CI, P=0.041), nausea and vomiting (OR2.631,95%CI1.267-5.464, P=0.009), diplopia (OR5.103,95%CI1.342-19.404, P=0.017), tinnitus (OR10.512,95%CI1.119-98.714, P=0.040), walking instability (OR2.547,95%CI1.328-4.884, P=0.005), nystagmus (OR9.368,95%CI3.251-26.991, P=0.000) and single limb sensory disturbance (OR3.145,95%CI1.051-9.412) are related to isolated pontine infarction; The different CISS typing is, extra and intracranial atherosclerosis type (25.2%vs41.3%P=0.005), perforator artery disease (65.3%vs44.0%, P=0.000), logistic regression analysis, results showed perforator artery disease (OR2.343,95%CI1.086-5.057, P=0.030) is associated with isolated pontine infarction. Conclusion:Compared with anterior circulation cerebral infarction, glycosylated hemoglobin associated with isolated pontine infarction, although persistent smokers, LDL-C with the other. Dizziness or vertigo, nausea and vomiting, diplopia, gait ataxia, nystagmus, tinnitus and single limb sensory disturbance are special to isolated pontine infarction; Perforator artery disease of CISS typing is associated with isolated pontine infarction.