Analysis The Association Of Between Angiotensin-converting Enzyme Gene (Ace)、Apolipoprotein E (ApoE) Gene Polymorphism And Abnormal Helit Syndrome

Objective:Study the association of between Angiotensin-converting enzyme gene (Ace), apolipoproteine (ApoE) gene polymorphism and abnormal helit Syndrome, Proposed theoretical assumptions Ace, ApoE gene polymorphism is associated with abnormal helit Syndrome. Methods:Using the methods of case-control studies, According to the standard of "Uighur Medical Diagnosis", choose abnormal helit Syndrome group515examples,308cases of normal helit Syndrome as control group, Useing HMR-polymerase chain reaction (PCR) for genotype of Ace gene and ApoE gene, Analysis the association of between Ace gene, ApoE gene tag SNP and abnormal helit Syndrome. Results:1) Ace^ApoE gene genotype frequency of abnormal helit Syndrome and normal helit Syndrome in accordance with Hardy Weinberg equilibrium test, Has AGroup representative;2) the Ace gene rs4293site main genotype for AG, main allele for A in abnormal helit Syndrome and normal helit Syndrome; rs4344site main genotype for AG, main allele for A; rs4303site main genotype for GG, a small number of allele is T; rs4461142site main genotype for CT, main allele is C; rs8075924site main genotype for CC, afew allele forT; rs4316818site main genotype for CT, main allele for T; rs12451328main genotype for CC, a few alleles for T; rs4353main genotype for AG, main allele G, A.ApoE gene rs405509site main genotype for AC, main allele for A in abnormal helit Syndrome and normal helit Syndrome; rs769450site main genotype for GG, a few alleles for A; Ace gene rs4353sites GG genotype frequency and G allele frequency in abnormal helit Syndrome higher than normal helit Syndrome (P<0.01), May be related to abnormal savda production. ApoE gene abnormal savda the crowd rs405509sites CCGenotype frequency and CAllele frequency were higher than normal group (P><0.01), May be related to abnormal helit Syndrome production;3) the Ace gene haploid type analysis, rs4293、rs4303、rs4344site, rs4316818and rs8075924site form haploid type, Compare the differences between the abnormal helit Syndrome and normal helit Syndrome (P>0.05).rs4461142and rs4353site form haploid type, abnormal helit Syndrome crowd AC*haploid type genotype frequency are significantly higher than normal helit Syndrome (P<0.01), Willing to have relationship with abnormal helit Syndrome production.ApoE gene rs769450and rs405509site form haploid type, abnormal savdACrowd AG*type genotype frequency are significantly higher than normal helit Syndrome (P<0.01), may be related to abnormal helit Syndrome formation have internal relations. conclusion:1) describe Ace gene and ApoE gene genotype and allele frequencies of xinjiang Uygur normal and abnormal helit Syndrome and their differences, accumulated data for future research and laid of solid foundation;2) Ace gene rs4353site and ApoE gene rs405509site genotype and allele frequency correlation with the abnormal helit Syndrome, may be related to abnormal helit Syndrome formation and have internal relations.