Study On The Influence Factors Of Renal Damage In Patients With Essential Hypertension

ObjectiveTo investigate the factors associated with renal damage in hypertensive patients, In orderto achieve early screening and monitoring,to prevent the pathogenesis and development ofkidney damage, select the appropriate therapy.MethodsChoose from March2012to December2013in our hospital diagnosed patients withessential hypertension, eligible patients were267cases. according to renal damage weredivided into kidney dysfunction group (SCr≥133μmol/L)26examples and normal renalfunction (SCr <133μmol/L)241cases. The two groups were compared using ANOVA foreach parameter, P <0.05as significant. With kidney damage as the dependent variable, age,gender, lacunar infarction, serum cystatin C, the highest levels of blood pressure, plasma renin,Ang Ⅱ, aldosterone, serum uric acid, cholesterol, carotid artery plaque count, renal bloodflow,renal arterial resistance as the independent variable. using logistic regression analysis,a=0.05, Screening out related factors of hypertensive renal damage.ResultsSingle factor analysis of variance, serum cystatin C, uric acid, renal blood flow, systolicpressure had significant influence on the highest level of hypertensive renal damage (P<0.01), asignificant effect of age, carotid artery plaque number, cardiac ejection fraction on hypertensiverenal damage (P<0.05), is hypertensive renal damage of non independent risk factors.Logistic regression analysis, the levels of serum cystatin C (OR=8.10,95%CI:1.69~38.79),uric acid (OR=4.74,95%CI:1.69~13.28), renal blood flow (OR=2.30,95%CI:1.09~4.85) wereindependent risk factors of hypertensive renal damage. ConclusionsSerum cystatin C, serum uric acid, renal blood flow is the influence factors of hypertensiverenal damage. Therefore, in these indicators is abnormal early intervention measures is of greatsignificance to prevention and treatment of hypertensive renal damage.