Mechanical Ventilation In Patients With MultiDrug Resistant(MDR) Acinetobacter Infection Distribution Characteristics And Drug Resistance Affecting Factors

Objectives Learn Mechanical ventilation patients multidrug-resistant Acinetobacterbaumannii infection epidemiological characteristics and risk factors, for patients withAcinetobacter baumannii infection in our region provide theoretical basis for treatmentand prevention.Methods Analyze121patients with mechanical ventilation in he bei united universityaffiliated hospital intensive medicine hospital of Acinetobacter baumannii infection fromNovember January2012to December2013as the research object, all conformto‘standard of hospital infection diagnostic criteria (trial)’. According to Acinetobacterbaumannii epidemiological survey, record each patient’sgender, age, Diseasediagnosis,GSC score, APACHE score, CPIS score, hospitalization-days, mechanicalventilationtime and general condition such as application of antibiotics and hormones, all patientswith mechanical ventilation (tracheotomy or tracheal intubation),use disposable asepticsputum suction tube from lower respiratory tract deep phlegm,according to the thirdedition ‘The national clinical test procedures’for bacterial cultivation, drug sensitive testusing the K-B disc diffusion method, according to the results of CLSI2007version of thestandard for interpretation, analyze the Acinetobacter baumannii from separationpathogen resistance, according to the istasusceptibility, patients were divided intomultidrug-resistant group and non multidrug-resistant group, learn about Tangshan regionof multidrug-resistant Acinetobacter baumannii infection risk factors. All data areanalyzed using SPSS13.0statistical software package. The measurement data isrepresented xˉ±s and compared using a paired t test.The count data is represented by ratioor percentageand compared using a pairedχ2test. Inspection standards, all with (P＜0.05)for the difference was statistically significant.Results1multidrug-resistant and non multidrug-resistant group of patients have nodifference on gender(P>0.05),In the age, multidrug-resistant group is higher than nonmultidrug-resistant group (P<0.05).2multidrug-resistant group of patients in infection,pre-hospital applications of antibiotics, combined use of antibiotics, antimicrobial drugapplication, GSC score, APACHE score, days of mechanical ventilation, days ofhospitalization are significantly higher Compared with control group(P<0.05).3logistic regression analysis showed that age, pre-hospital use of antibiotics, combined applicationof antibiotics, APACHE score, days of mechanical ventilation, hospitalization days areclosely related to multi drug resistant bacteria Acinetobacter infection.4our hospitalmultidrug-resistant Acinetobacter resistance is obviously, And it is very difficult to treatthese bacteria.5multidrug-resistant Acinetobacter baumannii has higher detection rate inautumn and winter season.6.Acinetobacter baumannii infection mortality rate is as highas19.12%.Conclusions Mechanical ventilation hospitalized elderly patients with multiple drugresistant acinetobacter baumannii resistant rate is high, patients with high age, pre-hospital applications of antibiotics, combined use of antibiotics, APACHE score, days ofmechanical ventilation and hospitalization days closely related to multipledrug resistantAcinetobacter baumannii infection, multidrug-resistant Acinetobacter baumannii hashigher detection rate in autumn and winter season. Multidrug-resistant Acinetobacterbaumannii difficult to treat and infection death rate is high, patients should be enhancedimmunity, reduce invasive procedures, improve the environment, help prevent infection.