Studies On Chemical Constituents Of Pterospermum Yunnanense Hsue, Diphasiastrum Complanatum (L.) Holub And Podocarpus Macrophyllus

The thesis mainly reported studies on chemical constituents of Pterospermumyunnanense Hsue, Diphasiastrum complanaturn (L.) Holub and Podocarpusmacrophyllus. Totally42constituents were isolated and elucidated from the threeplants, and one is a new compound.By solvent extraction, MCI column chromatography, silica gel columnchromatography, Sephadex LH-20column chromatography and HPLC,20compounds were isolated from the twigs and leaves of Pterospermum yunnanenseHsue, and all of them were identified by various spectral methods (1H-NMR,13C-NMR, HMQC, HMBC,1H-1H COSY, NOESY, and MS) to be as7-hydroxy-6-methyl-1-naphthoic acid methyl ester (1),6-hydroxy-7-(hydroxymethyl)-1-isopropyl-4-methylnaphthalene (2), syringic acid (3), vanillic acid (4),protocatechuic acid (5), isovanillin (6),4-hydroxy-3-methoxybenzaldehyde (7),4-hydroxybenzoic acid methyl ester (8), protocatechuic acid methyl ester (9),β-hydroxypropiovanillone (10), α-hydroxyacetosyringone (11), hexadecyl ferulate(12), scoparone (13),(+)-syringaresinol (14), taraxerol acetate (15), taraxerol (16),maslinic acid (17), stigmast-1,5-dien-3β-ol (18), β-sitosterol (19), daucosterol (20).Compound1was a new compound and others were isolated from the plant for thefirst time.From the all plants of Diphasiastrum complanatum (L.) Holub,6constituentswere isolated by various spectrum and were identified as lycopodine (21),6β-hydroxylycopodine (22),6α-hydroxylycopodine (23),15α-methyllycopodane-5β,6α-diol (24), lycoclavine (25),4α-hydroxylycopodine(26). All compounds wereisolated from the plant for the first time.16constituents were isolated by various spectrum from the barks of Podocarpusmacrophyllus, and were identified as15-hydroxydehydroabietic acid (27),15-methoxydehydroabietic acid (28),7α-hydroxy-dehydroabietic acid (29), methyltrans-ferulate (30),22-[[(2E)-3-(4-hydroxy-3-methoxy phenyl)-1-oxo-2-propen-1-yl]- oxy]-methyl ester (31), ferulic acid (32), vanillic acid (33),2,6-dihydroxy-3,4-di-methylbenzoic acid methyl ester (34),(1S,3aR,4S,9aR)-1,7-dimethoxy-4-(4’-hydroxyl-3’-methoxypheny1)-1,3,3a,4,9,9a-exa-hydronaphtho[2,3-c]furan-6-ol (35), mataire-sinol (36), rel-(3R,3’S,4R,4’S)-3,3’,4,4’-tetra-hydro-6,6’-di-methoxy[3,3’-bi-2H-benzo-pyran]-4,4’-diol (37), sideroxylin (38),7-ketositosterol (39), β-sitosterol (40),3β,5α-dihydroxy-6β-methoxyergosta-7,22-diene (41), isopseudolarifuroic acid A (42). Allcompounds were isolated from the plant for the first time.At last, alkaloids and pharmacological studies of Zanthoxylum were reviewed,including274alkaloids and their names, structures, plant resources, pharmacologicalactivities and references were cited.