Clinical Analysis Of Germs Of AECOPD

Objective: To investigate the hospital with chronic obstructive pulmonary disease in patients with acute exacerbation of bacteriological sputum culture results and antibiotic sensitivity of bacteria, so as to guide the rational use of antibiotics, effective infection control.Methods: The Second Affiliated Hospital of Bengbu Medical College, AECOPD patients with respiratory ward in November 2012-2014 April treated 350 cases, with complete clinical data, 192 cases were male, female 158 cases, aged 56 to 92 years old, recalls analysis of each patient’s sputum bacterial culture and sensitivity results clearly constitute a variety of bacteria and antibiotic sensitivity over the case.Result: 1. 350 cases of AECOPD patients, 215 cases of censorship, censorship was 61.42%, a total of 154 cases of isolated pathogens, pathogenic bacteria were not detected in 61 cases, the positive rate was 71.62%; 2. 154 cases of the strain in the detection of pathogens in Gram-negative bacteria 89, accounting for 57.80%, Pseudomonas up to a total separation of 36, followed by Escherichia coli 21(13.63%), Klebsiella pneumoniae 17(11.03%), Acinetobacter baumannii 15(8.53%); fungus 25(14.02%), mainly fungus Candida albicans 18 cases(11.03%); 40 cases(25.97%) Gram-positive bacteria. 3. Gram-negative bacteria is the most effective antibiotic imipenem, US Luopei Lan, followed cefepime, cefoperazone sulbactam, tigecycline, which imipenem against Pseudomonas aeruginosa the highest rate of bacteria sensitive, sensitive rate 99.57%, maltophilia Aeromonas generally resistant to antibiotics; effective against Gram-positive bacteria, antibiotic imipenem, vancomycin, imipenem against Staphylococcus bacteria sensitive rate of 95.65 percent, its definitely more sensitive to vancomycin. 4. The detection of Candida albicans fungi mainly detected commonly used antifungal agents such as flucytosine, nystatin, fluconazole, ketoconazole sensitive to higher rates, itraconazole, voriconazole highly sensitive.Conclusion: 1. Currently on the area of clinical sputum specimens were low submission rate and training, to be further improved.Patients infected with pathogens 2.AECOPD clinical Gram negative bacilli, Gram-positive cocci certain proportion, fungal infections can not be ignored. 3. Gram-negative bacilli infection on second-generation cephalosporins, third generation cephalosporins, penicillin-resistant, low drug sensitivity, carbapenem class, the higher the sensitivity of the fourth generation cephalosporins; Gram-positive cocci to penicillins, second generation cephalosporins poor sensitivity, aminoglycosides, fourth generation cephalosporins, cephamycins better sensitivity, highly sensitive to vancomycin; fungal infection compared with antifungal sensitive. 4. maltophilia Aeromonas sensitive to antibiotics is low, widespread drug resistance. 5. clinical pathogen detection should be strengthened, according to the results of drug susceptibility reasonable choice use of antimicrobial drugs.