25 Hydroxy Vitamin D3 Serum Level And Clinical Indexs Correlation Analysis In Primary Nephritic Syndrome Patients

Objective:To explore the primary membrane clinicopathological correlation between serum 25 hydroxy Vitamin D3 levels and serum albumin,24 hours urine protein,bone mineral metabolism, blood lipids and inflammatory markers, nutritional statusindicators of the first onset nephrotic patients.Methods:select 93 patients with nephritic syndrome (>3.5g/d, proteinuria, hy-poproteinemia,hyperlipidaemia) as the main clinical manifestations of the patients, and the row of renal biopsy was recorded before the age and gender of patients, body weight, serum 25- determination of hydroxy 25 (OH) level, bloodroutine test the kidney function, calcium, phosphorus, parathyroid hormone, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein, Creactive protein, serum albumin and 24 hour urine protein. For renal biopsy confirmed by pathology nephritic syndrome types as membranous nephropathy.Results:the average serum 25 (OH) in patients with D3 level (17.817 + 11.8154)nmol/L, packet:25 (OH) D3 deficiency (25 (OH) D3= 25 nmol/L) and 25 (OH) D3 deficiency (15nmol/L<25 (OH) D3<75nmol/L), the proportion is 74.19% and 25.81% respectively. Through correlation analysis, 25 (OH) D3 was positively associated with serum albumin (r=0.616, P=0.000), and negatively correlated with 24 hour urinary protein (r=-0.520, P=0.034), prealbmin was positively associated with (r=0.415, P=0.000), high density lipoprotein cholesterol was positively correlated (r=0.040, P= 0.007), and negatively correlated with lowdensity lipoprotein cholesterol (r=-0.228, P=0.028). Multiple stepwise linear regression analysis showed that,25 (OH) D3 by serum albumin (P=1.538, P=0.017),24 hour urine protein (beta=-17.825, P=0.045), prealbumin (beta=-0.001,P=0.001), low density lipoprotein cholesterol (beta=-4.565, P=0.016) effect.Conclusion:Patients with membranous nephropathy can be found the lack of vitamin D or lack of inspection after the first episode, and a higher detection rate. Serum albumin,24 hours urine protein, serum albumin and the low density lipoprotein are important factors to affect the levels of vitamin D.