The Correlation Study Between TCM Pattern And Renal Damage Of Henoch-schonlein Purpura

Objective: To explorethe correlation between the TCM pattern and renal damage of Henoch-Schonlein purpura, and to study the high risk factors of cause occurrence of renal damage in Henoch-Schonlein purpura.Method: In 134 cases of HSP children with urine examnation is normal and the disease course was in 1 months, collect their general information and laboratory findings and syndrome differentiation of TCM information.Random access to 3 months under the same treatment, depending on whether happen renal damage divided into urinalysis abnormality group(HSP group) and without the urinalysis abnormality group(HSPN group), comparing this two groups, observation the possibly factors related to renal damage.Results:1.All of the 134 cases appared purpura, 47 cases(35%) had abdominal pain, 65 patients occurrence joint symptom. A total of 40 cases occurred abnormal urine, for the performance of isolated hematuria(50%), isolated proteinuria(30%), the hematuria and proteinuria(30%). The incidence of renal damage is 29.8%. 2.In the 134 cases, there are 60 cases of wind-heat damaging collaterals, damp-heat damaging collaterals in 32 cases, blood-heat damaging collaterals in 40 cases, in 2 patients qi-yin dificiency collaterals. After 3 months, the probabilty of occurrence of renal damage, was 22% in wind-heat damaging collaterals, 22% in damp-heat damaging, and 45% in blood-heat damaging collaterals. All of the 2 cases in qi-yin deficiency type had happened renal damage. 3. There was significant difference between the abdominal pain, positive D-D, the type of blood-heat damaging collaterals, repeated rash(P﹤0.05). Gender, age of onset, onset season, rash amount, joint pain, blood platelet count(PLT), wind-heat damaging collaterals, damp-heat damaging collaterals, qi-yin deficiency type in two groups had no statistical significance(P﹥0.05). 4. Multivariate analysis showed that the occurrence of renal damage in children with Henoch-Schonlein purpura is associated with the abdominal pain(The value of OR is 2.404; 95%Cl:1.080-5.352,P=0.041) and the positive of D-D(The value of OR is 2.470; 95%Cl:1.039-5.872,P=0.032).Conclusion:1. Children with Henoch-Schonlein purpura have the diversity performance, generally with the performance of rash, abdominal pain, joint symptoms. The incidence of renal damage is high, should be early intervention, early treatment. 2. Clinical syndromes of allergic purpura is mainly including with wind-heat damaging collaterals, blood-heat damaging collaterals, damp-heat damaging collaterals. The incident rate of kidney damage in the pattern of blood-heat damaging collaterals is higher than others. There was statistical significance compared with the non blood-heat damaging collaterals.This kind of pattern maybe occurs renal damage than other types more easily. 3. The risk factors for Henoch-Schonlein purpura occur renal injury is the abdominal pain and the positive of D-D.4. The patient who without renal damage but with the symptoms who was patern of blood-heat damaging collaterals, or abdominal pain, or the positive of D-D should be followed closely, and aggressive treatment to reduce or prevent the occurrence of renal damage.