Prostate Cancer Patients With SPECT Bone Scans In The Correlation Of Serum PSA

Objective:Discussion prostate cancer prostate specific antigen (PSA) levels and single photon emission computed tomography (single photo emission computer tomography, SPECT) clinical value of bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer.Methods:We retrospectively reviewed data of 54 patients who had diagnosed with prostate cancer from 2012 to 2014, all of whom have already received a whole bone scanning with SPECT and a serum PSA concentration test, so as to analyze bone imaging characteristics in prostate cancer patients. The differences of serum PSA concentrations between prostate cancer patients bone scan positive and negative groups were analyzed by Student’s t test. All patients were classified according to SPECT images and grouped by different serum PSA concentrations (PSA concentration<10ng/ml,10～20ng/ml,20～ 50ng/ml,50～100ng/ml,>100ng/ml),correlation analysis of SPECT bone scans and serum PSA prostate cancer patients.Results:We collected data from SPECT scanning results of 54 prostate cancer patients. And the results demonstrated that the incidence of bone metastasis was 66.67%(36/54), and most of which were multiple lesions, there were only 3 cases of single lesion, spinal and pelvis were the most frequent metastatic sites. There was significant difference in serum PSA concentration between prostate cancer groups with bone scan positive and negative groups (t=-7.423, P<0.05). The bone metastasis rate of prostate cancer patients were as follows:There was only one of the 7 cases that PSA concentration was lower than or equal to lOng/ml had bone metastasis (14.29%). In the group of PSA concentration lower than or equal to 20ng/ml (18 cases), cases of bone metastasis were 4 (22.22%). In the group of PSA concentration higher than 20ng/ml (36 cases),32 cases of them suffered from bone metastasis (88.89%). All of the 15casesof PSA concentration higher than 100ng/ml had occurred bone metastasis. There existed significant correlation between bone SPECT imaging classification and PSA concentrations (r=0.748, P<0.001).When PSA> 20ng/ ml as the critical value,the diagnostic accuracy of bone metastases was the highest for 85.19%.The sensitivity and specificity were 88.89%,77.78%.Bone scan should be performed in order to figure out if any of bone metastases have occurred.Conclusion:The SPECT has played an important role in diagnosing prostate cancer with bone metastasis. SPECT bone imaging and serum PSA has a significant correlation.With the improvement of the classification of bone scintigraphy, bone metastasis of the more severe, the higher the PSA level. The possibility of prostate cancer patients with bone metastasis is very small when PSA concentration is lower than10ng/ml. However, when PSA concentration are higher than 20ng/ml, prostate cancer patients should accepted radionuclide bone imaging examination as early as possible to detect bone metastases in early time.