Comparing Two Kinds Of Detection Methods Of Mycobacterium Tuberculosis And Researching The Influential Factors Of Mycobacterium Tuberculosis Infection

Objective:To master the situation of Mycobacterium tuberculosis infection and the epidemiological characteristics in Longxi County, Gansu Province, Compare the application of two methods in testing mycobacterium tuberculosis infection. Explorating preliminarily the laboratory testing method of mycobacterium tuberculosis infection that is suitable for Longxi county population characteristics. Methods:1 Collecting basic information about the study by field surveys, including gender, age, occupation, hobbies, diet and health status; 2 Obtaining card marks, height, weight, blood pressure and other results by physical examination; 3 Determining subjects of the study whether were latent Mycobacterium tuberculosis infection by TST aasy; 4 Blood sampling, using y-interferon release assays (IGRA) to determine whether latent Mycobacterium tuberculosis infection, obtaining biochemical index results through blood biochemical test. Results:1. The results prompt latent Mycobacterium tuberculosis infection through TST and IGRA assay was consistent (Kappa= 0.620, P<0.05).2. Gender, age, occupation, BCG scar, Smoking, drinking, eating meat and eggs and soy products frequency, and different cases, TST method for the determination of latent Mycobacterium tuberculosis infection rates were statistically significant(P<0.05); sex, age, occupation, smoking, drinking and eating soy frequency, and different cases, IGRA method for the determination of latent Mycobacterium tuberculosis infection rates were significant(P <0.05).3. Logistic regression analysis showed that:(1) males, age, smoking in the results of TST measuring were risk factors of latent Mycobacterium tuberculosis infection, consumption of soy products high frequency was a protective factor; taking the students as a control, retirees and other career were risk factors of latent Mycobacterium tuberculosis infection, though farming, housework, business/ services, construction of mining workers, teachers, manufacturing and drivers were protective factors. (2) IGRA assay results showed:males, age, smoking were risk factors of latent Mycobacterium tuberculosis infection; taking the students as a control, processing and manufacturing were protective factors of latent Mycobacterium tuberculosis infection, the retirees, farming, housework, business/services, construction of mining workers, teachers and drivers were risk factors. Conclusion: Mycobacterium tuberculosis latent infection by TST and IGRA was consistent, the degree of consistency was general. Male, age, smoking were risk factors for latent Mycobacterium tuberculosis infection, consumption of soy products high frequency was protective factor through TST. Taking students as a control, occupation as a risk factor was inconsistent through TST and IGRA.