Professor Deng Gaopi About Summary And Innovation Of Tubal Pregnancy

Objective:Professor Deng Gaopi for domestic experts in tubal pregnancy, the purpose of this paper is to summarize professor Deng Gaopi in tubal pregnancy the experience of the basic research and the conclusion, summarize and concise professor Deng Gaopi in tubal pregnancy idea and innovation of basic research, hoping to professor Deng Gaopi and his research team to provide the reference in the subsequent research.Methods:1. Literature collection:(1) through WANFANG DATA, VIP, CNKI database full professor Deng Gaopi and his research team to collect relevant tubal pregnancy related literature contents of basic research. (2) through WANFANG DATA, VIP, CNKI database collection of fallopian tube pregnancy basic research literature content.2. to organize the collected literature, induction, summary, and refining the professor deng high PI based on tubal pregnancy, the thinking of research and innovation. Results:1. Professor Deng Gaopi and his team through the fallopian tsbe pregnancy sertoli cell and normal intrauterine pregnancy gestational sertoli cell morphological observation, growth curve drawing, invasive ability contrast, found that there is no obvious difference.2. Professor Deng Gaopi and his team using using high performance liquid-mass spectrometry analysis of filling and take blood disease kill germ elimination of traditional Chinese medicine compound containing medicine serum of rats inspection* found the drug-containing serum medicated group of Chinese traditional medicine ingredients with blood disease kill germ elimination Chinese herbal compound single main pharmacological ingredients.3.Professor Deng Gaopi and his team reference intrauterine pregnancy nourishing cells cultured in vitro method, successful people tubal pregnancy sertoli cell in vitro model was established.4. Professor Deng Gaopi and his team pioneered gravid trophocyte nude mice in vivo transplantation model.5. Professor Deng Gaopi and his team through the observation of blood disease kill germ elimination of traditional Chinese medicine compound function before and after the sertoli celt ultrastructure ot tubal pregnancy, confirmed that. the compound can ulrastructure of tubal pregnancy, and can inhibit gravid t.rophocyte aggressivity, and its inhibition concentration correlation.6. Professor Deng Gaopi and his team through the observation of blood disease killed after embryo of Chinese medicine compound treatment of tubal pregnancy tissue and blood disease kill germ elimination of tradi.tional Chinese medicine compound containing medicine serum of rats were cultured tubal pregnancy nourish cells the expression of ER, PR, found that the intensity of ER, PR expression are reduced.7 Professor Deng (;aopi and his team through the observation of bloodn disease kill the embryo of Chinese medicine compound after tubal pregnancy nourish cells in the expression of MMP - 2 intensity, found that the obvious rise; And traditional Chinese medicine compound on pregnancy embryo in blood disease elimination kill nourish cells in nude mice in vivo model of intervention studies have found that portable bag piece of MMP - 2 expression.8. Professor Deng Gaopi and his team through the observation of blood disease kill germ elimination of traditional Chinese medicine compound treatment, of tubal pregnancy after tuba] organization and with the blood disease kill germ elimination of tra.ditional Chinese medicine compound containing medicine serum of rats were cultured tubal pregnancy nourish ce].] s the Bc1 - 2 expression tevel, find the Bc1 - 2 expression are suppressed, at. the same time can increase the expression of Bax and Fas]. apoptosis protein, reduced the Bc1 - 2 / Bax, play the role of promoting sertoli cell apoptosis; And through to the three kinds of high, medium and ].ow concentration in di fferent drug delivery time conditions used for .observation of" fallopian tube pregnancy nourish cells, people found that the serto].i cell. proliferal:ion is restrained, and nourish to cell apoptosis, and apoptosis with concentration and time dependence.Conclusions :1. Professor Derng Gaopi arid his team to t he the Chinese medicine treatment of tubal pregnancy based pregnancy based research idea :is : the study of" blood disease kill germ elimination of traditional Chinese medicine compound for the treatment of tubal pregnancy, respect:iv:ely discussed in cellular, molecular and genetic level blood disease kill germ. elimination mechanism of action of t raditiional Chinese medicine compound reatment of tubal pregnancy.2. Professor Deng Gaopi and his research team found tubal. pregnancy nourish cells with normal intrauterine pregnancy nourish cells:in morphology, growth ability and the ability to no difference between the three aspects,3. Professor Deng Gaopi and his team found that blood disease kill germ elimination of traditional Chinese medicine compound compound containing medicine serum drug ingredients in line with single drug standard components.4. Professor Deng Gaopi and his research team improve the fallopian tube gnamev sertoli cell model in vitre5. Professor Deng Gaopi and his research team found that the first nourish cells in nude mice in vivo transplantation model.6. put forward blood disease kill germ elimination of traditional Chinese medicine compound can destroy tubal pregnancy ultrastructure, inhibit the gravid trophocyte aggressivity, this may be. for one of the mechanism of treatment of tubal pregnancy.7. Professor Deng Gaopi and his research team is put forward to reduce the expression of ER and PR for blood disease kill, germ elimination is one of the mechanism of action of traditional Chinese medicine compound treatment of tubal pregnancy.8. Professor Deng Gaopi and his team speculated that blood disease kill germ elimination of traditional Chinese medicine compound through the expression of MMP-2 raised nourish cells, nourish cells, extracellular matrix make the fallopian tube pregnancy excessive dissolved, destroy the gravid trophocyte; In tubal. mucosa, MMP-2 the expression is reduced, it cannot dissolve the tubal mucosa extracellular matrix, thereby reducing nourish cells, embryo sac fall off. Professor deng high PI presented on tubal pregnancy disease microenvironment "seed soil theory".8. Professor Deng Gaopi and his team put forward blood disease kill germ elimination of traditional Chinese medicine compound sertol.i cell apoptosis induction of fallopian tube pregnancy.